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In this study, researchers found that mitochondrial complex I plays a crucial role in regulating innate immunity and bone remodeling, with Ndufs4 deletion causing systemic inflammation and osteopetrosis through various metabolic shifts and cellular mechanisms.

This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.

This study found that Cidea is critical for regulating lipid storage and sebum secretion in sebaceous glands, with its deficiency causing hair issues and impaired skin functions in mice.

This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.

This study suggests that short-term treatments with specific small molecules may enhance the differentiation potential and stem cell properties of human amniotic fluid stem cells.

This review discusses the pharmacological actions and potential therapeutic benefits of ginsenoside compound K for metabolic disorders, reports no new clinical results, and suggests further research on its bioavailability and toxicity.

This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.

This study found that the green alga Botryococcus terribilis and its novel compounds significantly promoted hair growth marker gene expression in hair follicle dermal papilla cells without cytotoxic effects.

This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

This study found that papillary dermal fibroblast progenitors in newborn mouse skin can be isolated and cultured to generate male germline cell precursors, demonstrating their potential through differentiation into cells with meiotic capability.

This review evaluates the anti-aging properties of TSG from He shou wu, finding it may protect against age-related diseases through multiple mechanisms, though further research is needed for clinical application.

This review discusses the potential antiaging effects of Chinese herbal medicines and suggests their role in regulating aging-related genes through various signaling pathways; it reports no new clinical results.

This review summarizes evidence that apple and apple products may offer protective effects against various health issues, including cardiovascular diseases, cancer, mild cognitive impairment, and skin conditions, due to their phytochemical content and mechanisms like anti-inflammatory and antioxidant actions.

This study found that both natural and environmental selection have significantly influenced the goat genome, revealing genetic loci tied to adaptation, fitness, and productive traits, more so than artificial selection, across various goat populations.

This review found that different monosaccharide compositions in polysaccharides from 72 medicinal plants are linked to varying biological activities, with glucans, galactans, mannans, fructans, and pectins showing significant roles in immunomodulation, antioxidant effects, and other health benefits.

This study investigated how the antioxidant MitoQ and the enzyme CYP19A1 influence mitochondrial function in androgenetic alopecia. In a mouse model, both CYP19A1 overexpression and MitoQ treatment improved mitochondrial health and reversed DHT-induced hair loss factors, suggesting potential therapeutic targets for this condition.

This review synthesizes recent molecular and preclinical advances in alopecia areata and androgenetic alopecia, highlighting how interventions targeting specific intracellular signaling pathways and utilizing stem cell technologies can support precision regrowth and structural follicle reconstruction.

This review reports that the monosaccharide composition of polysaccharides significantly impacts their bioactivity, highlighting various roles for glucans, galactans, mannans, fructans, and pectin in immune regulation, antioxidant effects, and other biological functions.

In this exploratory in vitro study, treatment with spermidine increased cell viability and altered gene expression in human epidermal keratinocytes, suggesting potential benefits to cellular health and function, though effects on mitochondrial markers were not significant.

This review highlights the important role of the vitamin B complex in enhancing tissue repair, reducing inflammation, and improving surgical outcomes in plastic and reconstructive procedures by supporting cellular processes such as mitochondrial efficiency, neurotransmitter biosynthesis, and wound healing pathways.

This study found that activation of RORA significantly promotes the level of autophagy in rat hair follicle stem cells, suggesting a potential target for research on hair follicle development and treatments for conditions like alopecia.

In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.

In this study, researchers found that RORA directly regulates the expression of the Bnip3 gene, which is crucial for hair follicle stem cell health, using rat HFSCs as a model. They propose that targeting RORA could modulate HFSC status.

This study demonstrated that ellagic acid promoted hair regrowth in a DHT-induced androgenic alopecia mouse model by inhibiting ferroptosis through the activation of the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for androgenic alopecia.

This review article reports recent advancements in understanding, diagnosing, and treating various hair loss conditions, like androgenetic alopecia and alopecia areata, including their genetic factors and new therapeutic options, while also examining the impact of COVID-19 on hair loss.

This review discusses the impact of melatonin and its metabolites on skin aging, summarizing how they may serve as "aging neutralizers" through their anti-oxidative and anti-inflammatory properties, but reports no new clinical results.

This study found that β-sitosterol, a brain-penetrable phytosterol, reduced melanoma cell growth and brain metastasis formation by interfering with mitochondrial respiration, suggesting its potential as an adjuvant therapy to BRAF inhibitors for patients with melanoma brain metastases.

This review explores the therapeutic potential of brown adipose tissue for treating polycystic ovary syndrome and reports no new experimental results, emphasizing the need for future research to develop effective strategies.

This review synthesizes current research on PPAR-γ signaling in hair follicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.

This review discusses the fundamental hallmarks of aging as they relate to skin aging and highlights the prominent roles of oxidative damage and the extracellular matrix in photoaging, reporting no new results.