research SnapshotDx Quiz: February 2018
Blocking certain pathways with kinase inhibitors may help treat cutaneous lupus erythematosus.
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research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research Toll-Like Receptor 4 (TLR4): New Insights into Immunity and Aging
TLR4 is important in aging-related diseases and could be a new treatment target.
research TLR9 Activation in Large Wound Induces Tissue Repair and Hair Follicle Regeneration via γδT Cells
Activating TLR9 helps heal wounds and regrow hair by using specific immune cells.
research Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction?
Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
research The Role of Tight Junctions in Skin Barrier Function and Dermal Absorption
Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.
research Toll-Like Receptor Function in Acute Wounds
Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.
research The Profibrogenic Role of Neutrophil Extracellular Traps in Stenotic Crohn's Disease: A New Antifibrotic Target?
Targeting NETs may help reduce fibrosis in Crohn's disease.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research Association Between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends
Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.
research Studying the Genetic Predisposing Factors in the Pathogenesis of Acne Vulgaris
Genetics play a role in acne, but how exactly they contribute is not fully understood.
research New Developments in Our Understanding of Acne Pathogenesis and Treatment
We now understand more about what causes acne and this could lead to better, more personalized treatments.
research Suppression of Cutibacterium Acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin
FGF21 can help reduce skin inflammation caused by C. acnes.
research Therapeutic Anti-Inflammatory Potential of Formyl-Peptide Receptor Agonists
Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
research Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome
Effective PCOS treatments require targeting specific signaling pathways.
research Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils
The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.
research Neurosteroids on the Epilepsy Chessboard: Keeping Seizures in Check
Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.
research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations
Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin
Hair follicle development and microbes help regulatory T cells gather in newborn skin.
research Inflammation in Androgenetic Alopecia and Hair Loss: Linking Neurosciences, Endocrinology, and Dermatology
Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.
research CAQ Corner: Basic Concepts of Transplant Immunology
The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.
research Inflammasome Proteins as Biomarkers of Injury and Disease
Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.
research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease
Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.
research Extraskeletal Actions of Vitamin D
Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles
Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.
research Interrelation of Immunity and Tissue Repair or Regeneration
The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
research Aging Skin: A Window to the Body
Skin aging reflects overall body aging and can indicate internal health conditions.
research The Circadian Clock in Skin
The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
research Choreographing Immunity in the Skin Epithelial Barrier
The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
research Epidermal Keratinocytes Initiate Wound Healing and Pro-Inflammatory Immune Responses Following Percutaneous Schistosome Infection
Epidermal keratinocytes start wound healing and inflammation after schistosome infection.