November 2025 in “Journal of Investigative Dermatology” TEDAR is crucial for skin cell differentiation and barrier formation.
This study identified specific lncRNAs and mRNAs differentially expressed in miniaturized follicles compared to normal follicles in patients with androgenetic alopecia, with AL136131.3 potentially inhibiting hair growth and accelerating follicle transition to catagen through effects on glycolysis-related genes.
January 2021 in “Figshare” This study reported that exposure to melatonin promoted hair follicle fiber growth in an in vitro Cashmere goat model, potentially by influencing pathways related to the extracellular matrix and microvascular system.
July 2020 in “Research Square (Research Square)” This study reported distinct expression patterns and potential functions of lncRNAs during the hair follicle cycle in yaks, suggesting insights into lncRNA roles and conservation between yak and cashmere goat.
June 2020 in “Research Square (Research Square)” This study identified expression patterns of long non-coding RNAs during the hair follicle cycle in yak, revealing potential functions and sequence conservation with cashmere goats.
March 2020 in “Research Square (Research Square)” This study identified 2884 long non-coding RNAs (lncRNAs) associated with hair follicle cycling in yaks and highlighted sequence conservation with cashmere goats, suggesting potential pathways for hair growth regulation.
January 2018 in “Figshare” In this study, melatonin exposure promoted hair follicle fiber growth in Cashmere goats, suggesting that it may mediate hair follicle development through long non-coding RNAs affecting vascular and extracellular pathways.
January 2018 in “Figshare” This study found that melatonin exposure promoted growth in Cashmere goat hair follicles in vitro and suggested that lncRNAs play a key role in regulating this process, particularly through pathways involving the microvascular system and extracellular matrix.
April 2023 in “Journal of Investigative Dermatology” This study found that overexpression of the lncRNA AL136131.3 may inhibit hair shaft growth and promote hair follicle apoptosis in androgenetic alopecia by influencing key metabolic pathways.
41 citations
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February 2021 in “Translational research” This review discusses the role of noncoding RNAs (ncRNAs) in radiation response and highlights their potential as biomarkers for assessing radiation damage, but reports no new clinical results.
17 citations
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September 2022 in “Genes & Genomics” In this study, researchers identified specific long non-coding RNAs involved in feather development that do not follow traditional genetic inheritance patterns in chickens.
9 citations
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February 2023 in “Genes” This study reveals that long non-coding RNAs influence cashmere fiber traits in goats by interacting with target genes involved in pathways affecting fiber diameter and color.
October 2025 in “Animal Bioscience” This study identified important lncRNAs and genes associated with cashmere shedding in goats and explored their regulatory interactions, providing insights into the molecular mechanisms that may underlie this phenomenon.
2 citations
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July 2023 in “Animals” In this study, researchers investigated a regulatory network in cashmere goat embryos and found that fibroblast growth factor 10, alongside non-coding RNAs, significantly influences hair follicle cell proliferation, offering insights into the biology of hair follicles in cashmere goats.
January 2025 in “BMC Genomics” In this study, researchers identified thousands of mRNA, lncRNA, circRNA, and miRNA transcripts involved in different hair follicle stages of Rex rabbits and highlighted significant gene expression changes and pathway enrichments, providing insights into the regulatory mechanisms of hair development in these animals.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that TLR3 activation in human keratinocytes enhances exosome biosynthesis and expression of hair follicle stem cell markers, suggesting a potential mechanism for tissue regeneration.
This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.
24 citations
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May 2022 in “BMC Veterinary Research” This study identified key mRNAs and lncRNAs, along with related pathways, that play potentially important roles in hair follicle development and cycling in cashmere goats.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that TLR3-mediated damage sensing can stimulate prostaglandin and Wnt pathways, potentially coordinating hair follicle regeneration in mice with large skin wounds.
7 citations
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May 2022 in “PLOS ONE” This study found that Hetian sheep with higher wool density produce more and finer wool, with key genes potentially influencing their wool growth and density.
14 citations
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April 2019 in “Genes” This study identified a genetic locus associated with coat type in domestic dogs, showing certain variants linked to single-coated breeds and suggesting potential regulatory roles.
2 citations
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June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses recent advancements in skin epigenetics, focusing on how epigenetic mechanisms regulate gene expression during normal skin function and their dysregulation in conditions like skin disorders and cancer, but reports no new clinical results.
January 2025 in “Stem Cells International” In this review, researchers discuss the role of epigenetic modifications in epidermal stem cells' decline during skin aging and identify potential interventions targeting these disruptions, suggesting significant possibilities for antiaging strategies and dermatological treatments.
Among Super Merino and Small-Tailed Han sheep, this study identified differentially expressed long non-coding RNAs and mRNAs linked to hair follicle growth and fiber traits, suggesting their potential roles in regulating these important wool characteristics through RNA sequencing and gene enrichment analyses.
50 citations
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March 2018 in “BMC Genomics” This study expands knowledge of non-coding RNAs in goats and other mammals, enhancing understanding of their roles in hair follicle growth and regression.
24 citations
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April 2020 in “Cells” This study in cashmere goats found that DNA methylation levels were lower during hair follicle differentiation compared to induction, suggesting it plays a critical role in gene regulation for hair morphogenesis.
7 citations
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September 2022 in “International journal of molecular sciences” This study identified and analyzed numerous lncRNAs, miRNAs, and mRNAs involved in hair follicle development in cashmere goats, highlighting key regulatory pathways and suggesting roles for specific RNAs in enhancing hair follicle cell proliferation.
1 citations
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April 2023 in “Frontiers in Immunology” This review explored recent research on the immune mechanisms and potential therapeutic targets for alopecia areata, highlighting the roles of immune-related cells, autocrine and paracrine signaling, as well as factors like adipose-derived stem cells and gut microbiota in disease pathogenesis.
April 2026 in “BMC Genomics” This study identified key molecular differences between Long and Short hair type cashmere goats, suggesting hair type differentiation is linked to structural assembly and follicle remodeling.
July 2023 in “Frontiers in veterinary science” In this study, researchers analyzed skin samples from Dorper sheep to identify 395 differentially expressed long non-coding RNAs (lncRNAs) linked to hair follicle growth phases, suggesting these lncRNAs may play a role in the regulation of hair shedding through pathways like estrogen and PI3K-Akt signaling.