Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

January 2021 in “ Figshare ”

Wei Ge, Shan-He Wang, Bing Sun, Yuelang Zhang, Wei Shen, Hasan Khatib, Xin Wang

melatonin hair follicle growth secondary hair follicle focal adhesion extracellular matrix receptor pathways long non-coding RNAs vascular smooth muscle contraction signaling pathways pluripotency of stem cells hair follicle stem cells microvascular system extracellular matrix hair growth stem cells microenvironment

TLDR Melatonin helps Cashmere goat hair follicles grow by affecting stem cell signals and the surrounding microenvironment.

In 2021, a study was conducted to understand the role of melatonin in promoting hair follicle growth in Cashmere goats. The researchers established an in vitro Cashmere goat secondary hair follicle culture system and found that exposure to 500 ng/L melatonin promoted hair follicle fiber growth. The study revealed that melatonin promoted hair follicle elongation by regulating genes involved in focal adhesion and extracellular matrix receptor pathways. Additionally, it was found that melatonin mediated long non-coding RNAs (lncRNAs) mainly targeted vascular smooth muscle contraction and signaling pathways regulating the pluripotency of stem cells. The researchers concluded that melatonin not only regulated hair follicle development by affecting key signals from hair follicle stem cells, but also targeted pathways involved in the microvascular system and extracellular matrix, which are crucial for the microenvironment of hair follicle stem cells.

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