Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

January 2018 in “ Figshare ”

Wei Ge, Shan-He Wang, Bing Sun, Yuelang Zhang, Wei Ge, Hasan Khatib, Xin Wang

melatonin hair follicle growth secondary hair follicle focal adhesion extracellular matrix receptor pathways long non-coding RNAs vascular smooth muscle contraction signaling pathways pluripotency of stem cells microvascular system extracellular matrix hair growth stem cells microenvironment

TLDR Melatonin helps Cashmere goat hair follicles grow by affecting genes and cell signals important for their development and environment.

In 2018, a study was conducted to understand the role of melatonin in promoting hair follicle growth in Cashmere goats. The researchers established an in vitro Cashmere goat secondary hair follicle culture system and found that exposure to 500 ng/L melatonin promoted hair follicle fiber growth. The study revealed that melatonin promoted hair follicle elongation by regulating genes involved in focal adhesion and extracellular matrix receptor pathways. Additionally, it was found that melatonin mediated long non-coding RNAs (lncRNAs) mainly targeted vascular smooth muscle contraction and signaling pathways regulating the pluripotency of stem cells. The study concluded that melatonin not only regulated hair follicle development by affecting key signals secreted from hair follicle stem cells, but also targeted pathways involved in the microvascular system and extracellular matrix, which are crucial for the microenvironment of hair follicle stem cells.

View this study on tandf.figshare.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 251 results

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 90 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community 4.5 month finasteride update! What a difference hair makes! To all the people that say just shave it bro, just no.

in Progress Pictures 1590 upvotes 4 years ago

A user's progress pictures and four month finasteride update showing dramatic hair regrowth, as well as their experiences with other treatments like minoxidil. The conversation also includes advice on diet, testosterone levels, and the importance of avoiding baldness for attraction and confidence.

community My strong recommendation for those shedding hair

in Treatment 96 upvotes 3 years ago

A user with aggressive male pattern baldness found that topical melatonin significantly reduced their hair shedding to 1 or 2 hairs per day and noticed some thickening of side hair. They tried many treatments like finasteride and minoxidil with little success, but topical melatonin showed immediate results in reducing hair loss.

community Is there any point to microneedling if you're on oral minoxidil?

in Microneedling 45 upvotes 1 year ago

Microneedling's effectiveness for hair regrowth is debated, with mixed results from studies. Some believe it helps with blood flow and scalp health, while others see it as largely ineffective.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

Related Research

2 / 2 results

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations, April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat

22 citations, July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture”

Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.