3 citations
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April 2025 in “Advanced Healthcare Materials” In this study, researchers developed hyaluronic acid derivatives functionalized with nitric oxide photodonors for light-activated skin treatments, finding that the compounds released NO under blue light and enhanced keratinocyte proliferation and migration, suggesting potential for therapeutic use.
February 2025 in “International Journal of Biological Macromolecules” This study developed a NIR light-triggered NO-releasing hydrogel that promotes angiogenesis, repairs damaged dermal papilla cells, reduces inflammation, and improves the nutrient supply and follicular environment in animal models, offering a promising treatment strategy for androgenic alopecia.
October 2023 in “Bioactive Materials” This study developed a novel liposome-based delivery system for Minoxidil and nitric oxide, which showed promising results in promoting hair regrowth in an androgenetic alopecia model by enhancing transdermal absorption, prolonging skin retention, and reducing inflammation.
June 2025 in “Bioactive Materials”
1 citations
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January 2019 in “Advances in Medical Sciences” This study found that a combination of azelaic acid, minoxidil, and caffeine significantly reduced skin flap necrosis in rats, likely by increasing nitric oxide content and iNOS expression, compared to individual treatments.
1 citations
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February 2015 in “PubMed” This study found that azelaic acid and finasteride significantly increased iNOS expression and nitric oxide levels, which was associated with improved survival of skin flap grafts in rats.
1 citations
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June 2023 in “Biomolecules & therapeutics” This article reviews the role of nitric oxide in skin health, including its influence on immune responses and potential therapeutic applications for contact dermatitis, but reports no new clinical results.
1 citations
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February 2023 in “Plants” This study reported that rice bran oil from the Thai rice variety BB4CMU showed potential in promoting melanin production and inhibiting steroid 5α-reductase, suggesting a natural option for hair revitalization.
November 2024 in “ACS Materials Letters” This study developed a nitric oxide delivery system using PVA films and HA liposomes, which enhanced hair follicle vitality and repaired blood vessels in androgenic alopecia by promoting angiogenesis and reducing inflammation through the HIF-1 signaling pathway.
August 2025 in “Macromolecular Bioscience” This study found that microneedles co-delivering minoxidil and a nitric oxide donor effectively promoted hair growth and follicle transition to the growth phase in an alopecia mouse model, suggesting a promising new approach for androgenetic alopecia treatment.
November 2025 in “SKIN The Journal of Cutaneous Medicine” This review highlights the potential benefits of low-level light therapy for treating various alopecias, with reported improvements in hair density and count, especially when combined with minoxidil or finasteride, but it offers no new clinical results.
January 2005 in “Industrial Catalysis” This study found that regenerating the Pd/C finasteride synthesis catalyst using methanol extraction and nitric acid oxidation achieved a pregnendone conversion of 97.5%.
9 citations
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June 2022 in “Plants” This study found that shallot extract may promote hair growth in androgenetic alopecia by reducing inflammation and modulating gene expression related to key hair growth pathways.
8 citations
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June 2022 in “Cosmetics” This study found that coffee berry extract demonstrated anti-aging properties in skin and hair cells, showing significant anti-collagenase activity and stimulating hair-related gene expression, suggesting its potential for use in cosmeceuticals.
6 citations
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December 2020 in “Biological & Pharmaceutical Bulletin” This study found that certain fatty acids and triterpenoid-glycosides from Eclipta prostrata L. leaves exhibit potent inhibitory effects on the protein tyrosine phosphatase 1B enzyme, suggesting potential anti-diabetic and anti-obesity benefits.
August 2025 in “Tropical Journal of Natural Product Research” This study found that hydromethanolic extracts from Carthamus caeruleus L. rhizomes exhibited notable antioxidant and anti-inflammatory effects in both in vitro and in vivo experiments, supporting its traditional medicinal uses and suggesting its potential as a source of therapeutic agents.
1 citations
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July 2025 in “Advanced Science” This study developed multifunctional microneedle patches with CTB nanozymes that successfully eradicated MRSA infections in wounds by combining near-infrared laser-induced nitric oxide release and local hyperthermia, while also regulating oxidative stress, inflammation, and angiogenesis through specific signaling pathways.
22 citations
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March 2018 in “American Journal of Clinical Dermatology” New acne treatments show promise as alternatives to traditional therapies.
December 2022 in “Acta Ophthalmologica” In this study, dutasteride treatment in retinitis pigmentosa mice increased photoreceptor survival and reduced glial activation, suggesting it may offer a neuroprotective effect.
February 2010 in “Journal of The American Academy of Dermatology” This review examines microbial production and applications of gluconic acid, focusing on the enzymatic processes involved, and offers no new experimental results.
3 citations
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January 2023 in “Agronomy” This research reported that KDML105 bran extract demonstrated antioxidant activities, reduced nitric oxide production, and influenced gene expression related to the hair cycle in cultured dermal papilla cells, suggesting potential as an anti-hair loss agent by supporting the anagen phase and angiogenesis.
2 citations
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February 2022 in “Biology” This study found that blue laser irradiation reduced ATP levels and cell viability in mouse skin by increasing oxidative stress through the production of reactive oxygen species.
April 2017 in “Journal of Investigative Dermatology” This study found that retinoic acid and a retinol complex formulation showed different permeation and compound localization in a skin equivalent model, with unique lipid changes observed with only the retinol formulation.
November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that the leaf extract of Tectona grandis and its major bioactive constituents moderately inhibit the 5α-reductase enzyme, which is linked to androgenetic alopecia, and also possess anti-inflammatory properties, showing promise as dual-action candidates for managing this condition.
June 2025 in “Pharmacon Jurnal Farmasi Indonesia” This systematic review found that mangkokan leaf formulations, especially ethosomal gel or phytosome lotion at 25% concentration, were most effective in stimulating hair growth and improving hair health through various biological mechanisms.
March 2008 in “British Journal of Pharmacology” This guide provides an overview of the complex roles and mechanisms of various receptors and channels in pharmacology but does not report new experimental results.
1 citations
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October 2024 in “Journal of King Saud University - Science” In this in vitro study, extracts from Tridax procumbens demonstrated potential antioxidant and anticancer activity against various human cancer cell lines, with notable efficacy in specific fractions.
1 citations
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June 2019 in “Food Research” In this study, tempeh oil rich in PUFAs, particularly from black soybean, significantly down-regulated MMP-9 gene expression in UVB-irradiated mice skin, indicating potential for use in preventing skin photoaging.
59 citations
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September 2008 in “Journal of Burn Care & Research” This study found that a new topical nitric oxide gel significantly accelerated burn wound healing in mice by enhancing re-epithelialization, hair follicle regeneration, collagen deposition, and angiogenesis compared to controls.
118 citations
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May 2015 in “European journal of pharmaceutics and biopharmaceutics” This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.