Improvement of Tissue Survival of Skin Flaps by 5α-Reductase Inhibitors: Possible Involvement of Nitric Oxide and Inducible Nitric Oxide Synthase

February 2015 in “ PubMed ”

Ali Asghar Karimi, Marjan Ajami, Yasin Asadi, Nahid Aboutaleb, Fazel Gorjipour, Roya Malekloo, Hamidreza Pazoki‐Toroudi

5α-reductase inhibitors azelaic acid finasteride nitric oxide inducible nitric oxide synthase iNOS Propecia

TLDR 5α-reductase inhibitors may help skin flaps survive better by affecting nitric oxide.

The study investigated the effects of 5α-reductase inhibitors, azelaic acid and finasteride, on the survival of skin flap grafts in a rat model, focusing on the role of nitric oxide (NO) and inducible nitric oxide synthase (iNOS). Conducted on 42 male rats divided into six groups, the research found that both azelaic acid and finasteride significantly increased iNOS expression and NO levels in the graft tissue, which correlated with improved tissue survival. The findings suggested that changes in NO metabolism were involved in the enhanced survival of skin flaps mediated by these inhibitors.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid

7 citations , January 2012 in “PubMed”

Azelaic acid and finasteride can help preserve skin flaps after surgery by increasing BCL-2 protein and decreasing bax protein.

research The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency

28 citations , January 2009 in “Cellular & Molecular Biology Letters”

DHT deficiency increases iNOS expression in rat testis and epididymis.

Related Community Posts Join

6 / 182 results

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 102 upvotes 4 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community Dutasteride power compared to finasteride

in Finasteride/Dutasteride 15 upvotes 7 months ago

Dutasteride is generally considered more effective than finasteride for hair regrowth, with some users experiencing better results, especially at higher doses. However, individual responses vary, and some users report side effects or no response to either treatment.

community We are manipulating our hormones, surely it's prudent to track bloodwork ?

in Finasteride/Dutasteride 64 upvotes 1 year ago

The conversation discusses whether individuals using hair loss treatments like Dutasteride (Dut) or Finasteride (Fin) should regularly check their hormone levels through bloodwork. Some argue it's important to monitor the effects of these medications on hormone levels, while others believe it's unnecessary if there are no side effects, citing cost and practicality concerns.

community Andrew Schulz stated he had been using a ‘’hair pill’’ for 15 years and it may have caused him infertility

in Satire 134 upvotes 2 years ago

The conversation discusses the potential link between hair loss treatment pills, specifically finasteride, and infertility. Users share their experiences and opinions, with some suggesting that finasteride can temporarily lower sperm count, while others argue that other factors like age and lifestyle could also contribute to infertility.

community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 1 year ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 210 upvotes 1 year ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

Related Research

1 / 1 results

research Improvement of Tissue Survival of Skin Flaps by 5α-Reductase Inhibitors: Possible Involvement of Nitric Oxide and Inducible Nitric Oxide Synthase

1 citations , February 2015 in “PubMed”

5α-reductase inhibitors may help skin flaps survive better by affecting nitric oxide.