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In this study, researchers developed a programmable system using engineered nanovesicles from hair follicle stem cells to modulate immune responses, which showed promise in precisely controlling inflammation, promoting immune balance, and accelerating wound healing, particularly for infected wounds.

This study found that adipose-derived mesenchymal stem cells from type 2 diabetes mice were slightly less effective, yet had comparable therapeutic effects on wound healing compared to non-diabetic controls.

In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.

This paper explores the complex immune processes and cellular diversity that enable the skin to heal and resist invasion, and highlights its potential as a model for studying regeneration.

This review explores the potential link between psoriasis and metabolic syndrome, focusing on how disturbances in growth factors may connect these conditions and contribute to symptoms like keratinocyte proliferation and inflammation.

In this study, finasteride was found to reduce cholesterol levels and delay atherosclerosis in LDL receptor-deficient mice, and men using finasteride reported lower cholesterol levels, suggesting potential cardiovascular benefits by improving lipid profiles.

This study found that monocytes/macrophages with a pro-inflammatory M1-like phenotype may play a crucial role in the pathogenesis of hidradenitis suppurativa, suggesting potential therapeutic targets.

This study found that FGF-9 treatment in diabetic mice improved heart function after myocardial infarction by decreasing monocyte infiltration and promoting anti-inflammatory macrophage differentiation.

This study found that C-reactive protein may enhance monocyte adhesion to endothelial cells through NOX-mediated oxidative stress, suggesting a potential mechanism for atherogenesis.

This study found that topical application of TGF-β mimic promoted enhanced wound healing and tissue regeneration in mice, suggesting its potential as a therapeutic option for improving wound healing.

Schwann cell and M2 macrophage interactions contribute to keloid growth by increasing matrix deposition.

This study found that modifying adipose-derived stem cells to overexpress the adhesion protein JAM-A increased the adhesion and resilience of dermal papilla cells in the context of androgenic alopecia, potentially facilitating hair regrowth despite challenges such as damage from dihydrotestosterone and macrophages.

This study found that carbon dots derived from fucoidan effectively inhibit Enterococcus faecalis and its biofilm, offering a promising approach for managing biofilm-associated persistent endodontic infections.

This study found that dermal injection of M-CSF stimulated CD11b + myeloid cells can induce alopecia areata in mice by potentially activating B lymphocytes, offering insight into the disease's pathogenesis.

In this study, researchers developed a 3D in-vitro system for generating functional AT-resident macrophages without cell sorting, providing a valuable tool to study their differentiation and function in various physiological and pathological conditions.

This study found that implanting hair-follicle-associated pluripotent stem cell sheets facilitated wound healing and early macrophage activity while reducing inflammation in a diabetic mouse model, suggesting clinical potential for difficult-to-heal diabetic ulcers.

This study found that iron retention in macrophages impairs hair follicle growth and delays wound healing in mice, highlighting the importance of macrophage iron release for skin health.

This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.

This study found that adipose-derived mesenchymal stromal cell secretome, particularly when preconditioned with IFNγ, significantly influences cell motility and anti-inflammatory responses, enhancing its potential as a regenerative therapy.

In this review, the researchers highlight the role of fibroblasts in regulating the extracellular matrix and immune responses, emphasizing the impact on macrophages and potential therapeutic insights for fibrotic diseases and cancer.

This review discusses the relationship between aging, chronic inflammation, and immunosuppression, suggesting that these interconnected processes may contribute to tumorigenesis and premature aging, but reports no new experimental results.

This review examines the roles of macrophages and Langerhans cells in skin homeostasis and suggests that understanding these functions can aid in developing therapies for skin and hair regeneration, but it reports no new research findings.

In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.

This review discusses the role of dermal macrophages in stress-induced hair regeneration and reports no new clinical findings, highlighting the need for further research into macrophage dynamics for potential hair loss therapies.

This review covers the potential of SVF and ADSC therapies in regenerative medicine and highlights the challenges of regulation and efficacy, without reporting new clinical results.

This review examines current and potential approaches to managing chronic wound inflammation through macrophage-targeted strategies using ECM-inspired wound dressings, but it reports no new clinical results.

This study found that transforming growth factor-β1 and CX3CR1 are crucial for recruiting specific macrophages essential for wound-induced hair growth in mice.

In this study, researchers used a murine model of irritant contact dermatitis to reveal that hair follicle regions serve as key sites for neutrophil transepidermal migration, which requires MMP-9 expression stimulated by dermal monocytes.

This review highlights that disturbances in neuroimmune communication, particularly between sympathetic nerves and macrophages, may contribute to autoimmune diseases like rheumatoid arthritis and type 1 diabetes, and suggests potential therapeutic avenues by restoring this communication in preclinical and early clinical studies.