M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice

    December 2021 in “ Research Square (Research Square) ”
    Yunyuan Li, Ruhangiz T. Kilani, Rana Alamdaran, Arveen Shokravi, Aziz Ghahary
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    The study demonstrates that M-CSF-stimulated CD11b+ myeloid cells can induce alopecia areata (AA) in C3H/HeJ mice, highlighting their significant role in the disease's pathogenesis. Researchers found that these cells, derived from AA-affected skin or cultured with M-CSF, can activate B lymphocytes, leading to increased splenocyte proliferation and IgG levels. The findings suggest that, alongside T cells, myeloid cells and B cell activation are crucial in AA development. The study provides insights into the cellular mechanisms of AA and suggests that targeting M-CSF and CD11b+ myeloid cells could be a potential therapeutic strategy.
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