14 citations
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October 2024 in “Nano Convergence” This study found that an injectable hydrogel dressing with silver nanoparticles showed promise in healing MRSA-infected wounds by reducing inflammation, supporting tissue regeneration, and maintaining prolonged antibacterial activity, highlighting its potential as an effective treatment strategy.
This study explored chitosan-based dissolving microneedle arrays loaded with Agave tequilana root extract, finding that extract concentration influenced microneedle geometry and bioactivity, maintaining antioxidant and enzyme inhibitory effects while reducing collagenase inhibition, particularly in the 0.25% formulation.
November 2022 in “Journal of Investigative Dermatology” This study generated a transcriptomic map of human hair follicle compartments, providing a database for identifying compartment-specific gene expression which may aid in developing targeted treatments for hair follicle disorders.
September 2022 in “The Egyptian Journal of Hospital Medicine” This review article discusses microneedling as a non-surgical treatment option in dermatology, highlighting its benefits for scar improvement through collagen induction and reporting its popularity among practitioners due to its cost-effectiveness and simplicity.
July 2026 in “Lasers in Medical Science” In this study, the Peninsula Timerevert Needle was found to provide effective treatment for skin photoaging and acne scars with less pain and shorter treatment duration compared to EndyMed, although it caused more bleeding.
5 citations
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November 2023 in “Journal of Investigative Dermatology” This study observed that cutaneous microwounds created by fractional photothermolysis heal differently from typical wounds, displaying rapid re-epithelialization and limited inflammation, which may help reduce scar formation by delaying collagen remodeling and minimizing myofibroblast activation.
January 2018 in “Sohag Medical Journal” 16 citations
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November 2020 in “In Vitro Cellular & Developmental Biology - Animal” This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.
1 citations
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August 2024 in “Polymers” This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.
45 citations
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November 2022 in “Acta Biomaterialia” This study developed a biomimetic 3-D co-culture system that enhances the hair-inductive properties of human dermal papilla cell aggregates, potentially improving hair follicle tissue engineering.
16 citations
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February 2014 in “Journal of Investigative Dermatology” This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.
4 citations
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December 2021 in “Applied sciences” This study observed that a combination of micro-needling and low-level light/laser therapy significantly increased hair density in patients with mild to moderate androgenic alopecia, showing an increase of 12 hairs/cm² after 16 weeks, compared to baseline.
January 2019 in “The Review of Laser Engineering” This study observed that multiphoton excitation microscopy revealed changes in vascular structure and hair papillae in mice subcutaneous tissue following cyclophosphamide treatment for chemotherapy-induced alopecia.
17 citations
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July 2021 in “Polymers” This study found that treating chitin from crab shells with ultrasonication at specific conditions effectively produced fine nanofibers with a high yield.
83 citations
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September 2021 in “Advanced functional materials” This study introduced a multifunctional DNA hydrogel dressing that may enhance wound healing by promoting tissue regeneration, nerve repair, and immune response in diabetic infectious wounds.
50 citations
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December 2017 in “Nanoscale” This study found that polymeric micelle formulations significantly improved the targeted delivery of adapalene to hair follicles compared to standard Differin® products, which suggests potential advantages in treating hair follicle-related conditions and reducing side effects.
75 citations
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September 2015 in “Acta biomaterialia” This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.
21 citations
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August 2024 in “Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology” This paper reviews the advancements and applications of single-cell transcriptomics in animal research, highlighting its potential to enhance understanding of animal nutrition, health, genetics, and disease models.
8 citations
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May 2024 in “ACS Applied Materials & Interfaces” This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.
8 citations
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March 2023 in “Polymers” This study suggests that a chitosan-coated omeprazole-loaded nanoemulgel formulation may effectively treat certain skin infections due to its demonstrated antimicrobial properties and enhanced antibacterial activity.
4 citations
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January 2025 in “The Journal of Cell Biology” This study found that deleting ceramide synthase 4 in skin epidermis stem cells disrupts hair follicle and skin barrier function, leading to immune responses similar to atopic dermatitis, due to imbalances in lipid composition affecting differentiation.
2 citations
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April 2022 in “Biomedicines” This study demonstrated that exposing hair follicle organ cultures to extremely low-frequency electromagnetic fields at 10 G intensity for 60 minutes promoted hair growth, suggesting its potential as a treatment for hair loss.
This study found that while 3D spheroid culture preserved sweat gland cell-specific markers better than 2D culture, their growth and structural organization were suboptimal, highlighting the need for improved culture systems.
March 2025 in “FEBS Journal” This study found that Epiprofin acts as a negative regulator of parathyroid hormone transcription, with potential implications for controlling PTH production in hyperparathyroidism.
March 2025 in “Analytical Methods in Environmental Chemistry Journal” This study developed a spectrophotometric method to determine minoxidil in pharmaceuticals, creating a highly sensitive, simple, and cost-effective approach using a synthesized charge transfer complex with a notable absorption peak at 505 nm.
April 2024 in “Scientific reports (Nature Publishing Group)” In this study, a combined rosemary and neem extract outperformed ketoconazole and minoxidil in treating dandruff, scalp disorders, and promoting hair growth, demonstrating potent antifungal and anti-inflammatory properties in lab settings.
January 2024 in “Biomaterials Research” This study found that human hair follicle dermal papilla cells cultivated as 3D spheroids in hexanoyl glycol chitosan-coated dishes formed hair-like structures, with minoxidil enhancing growth, and successfully integrated into artificial skin models, suggesting advancements for hair loss treatments and skin restoration therapies.
December 2023 in “Aggregate” In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.
November 2023 in “Materials Today Bio” This article discusses photobiomodulation as a potential adjunct to hair follicle organoid culture for androgenic alopecia, reporting no new results and suggesting further study is needed.
August 2023 in “Military Medical Research” This review highlights that skin organoids, advanced three-dimensional models mimicking human skin, are emerging as effective alternatives to traditional culture models and human skin, overcoming limitations of two-dimensional systems and ethical concerns, and are being increasingly used in areas like developmental biology and disease modeling.