Delayed Collagen Production Without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Microwounds

    Chen‐Hsiang Kuan, Kang‐Yu Tai, Shao-Chi Lu … Sung‐Jan Lin
    Studysummary This study observed that cutaneous microwounds created by fractional photothermolysis heal differently from typical wounds, displaying rapid re-epithelialization and limited inflammation, which may help reduce scar formation by delaying collagen remodeling and minimizing myofibroblast activation.
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    Research cited in this study 9

    1. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    2. Long-Term Intravital Imaging of the Cornea, Skin, and Hair Follicle by Multiphoton Microscope Methods in molecular biology · 2019
    3. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    4. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    5. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    6. Hair Regrowth Through Wound Healing Process After Ablative Fractional Laser Treatment in a Murine Model Lasers in Surgery and Medicine · 2015
    7. Enhancing Hair Follicle Regeneration by Nonablative Fractional Laser: Assessment of Irradiation Parameters and Tissue Response Lasers in Surgery and Medicine · 2015
    8. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    9. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012