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This review provides an overview of how advancing imaging technologies, such as tissue clearing and intravital microscopy, are enhancing our understanding of tumor architecture and interactions between cancer cells and the tumor microenvironment, aiding both fundamental cancer research and the development of therapies.

This study provides ex vivo proof-of-principle that low-intensity ultrasound may protect human hair follicles from paclitaxel-induced damage, potentially reducing chemotherapy-related alopecia.

This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.

This study found that in beagles with benign prostate hyperplasia, finasteride treatment increased blood volume and decreased vessel leakiness in the prostate's parenchymal zone as shown by dynamic contrast-enhanced MRI.

This study found that using a PEG-400/oleic acid mixture as an optical clearing agent enhanced the detection depth of particles in skin without causing dehydration, based on tests in rats and further testing in vivo.

This study discovered that TREM2 macrophages influenced by squalene play a role in acne's development by hindering the killing of Cutibacterium acnes, helping explain why benzoyl peroxide is effective in treatment.

This review highlights the promise of small extracellular vesicles (sEVs) as biomarkers for sepsis, emphasizing their potential to improve early detection and guide therapeutic decisions by reflecting the immune status and pathogen presence in patients.

This study found that scanning electron microscopy with argon sputter etching visualizes hair lipids at the cell membrane complex as distinctive convex structures, shedding light on their role and localization in human hair.

In this study, researchers developed a DNA/GelMA-based cryogel platform that uses phototherapy to combat MRSA infection and promote scarless wound healing, showing enhanced bactericidal activity, tissue regeneration, and anti-inflammatory effects in vivo, suggesting a promising approach for treating infected skin wounds.

This review identifies that anaerobic bacteria from the gut and oral microbiota, not typical skin pathogens, are frequently present in hidradenitis suppurativa lesions, suggesting a role in inflammation and potential treatment targets.

In this study, a novel hydrogel dressing combining photodynamic therapy with organic semiconductor nanoparticles and silk fibroin demonstrated effective antibacterial action and enhanced wound healing and hair follicle regeneration in a mouse model, showing promise as an advanced wound care solution.

This study found that a gelatin microparticle-containing self-microemulsifying formulation combined with Soluplus improved the oral absorption of dutasteride.

This case report documents a rare presentation of congenital milia en plaque on the scalp of a five-year-old boy, with blaschkoid extension to the nuchal area, highlighting its uncommon location and onset.

This study found that exosomes from human umbilical cord mesenchymal stem cells reduced oxidative stress and inflammation in UVB-induced skin injury in cell and mouse models, suggesting their potential for treating UV-damaged skin by influencing Nrf2 and NF-κB pathways.

Developing microRNA-based treatments is hard but has potential.

This study found that adapalene-loaded microemulsions significantly enhanced the drug's penetration through guinea pig skin compared to an aqueous suspension, with factors like surfactant ratios and the water-oil phase balance affecting the transfollicular drug delivery efficiency.

This study identified differentially expressed microRNAs between back and belly skin in Rex rabbits, highlighting their potential roles in skin development processes.

This study developed the TLMG hydrogel, a seamless in situ biointerface platform, demonstrating robust adhesion, high conductivity, and therapeutic effects for intelligent wound management in complex animal models and human tests, indicating its promise for integrated bioelectronic medicine.

In this study, researchers developed a method to create skin organoids using spinning bioreactors, facilitating efficient high-throughput drug screening, and found that Minoxidil activates the Wnt/beta-catenin signaling pathway in these models.

This study found that 11% of cutaneous focal mucinosis lesions demonstrated follicular induction, which can mimic basal cell carcinoma histologically and complicate diagnosis.

This study observed that exosome treatment in skin led to increased dermal vascularity and mild inflammation, with one alopecia patient showing hair follicle growth at treated areas.

In this study, researchers used advanced four-dimensional optical imaging techniques to observe changes in skin afflicted with acne, finding increased epidermal thickness, keratinized hair follicles, inflammation, and aggregated blood flow, helping to distinguish between inflammation and reparative phases of acne progression.

This article reviews the potential of using PBM in 3D tissue engineering to improve cell viability under stress conditions but reports no new experimental findings.

This study found that mouse embryoid bodies adhered quickly and differentiated efficiently into cardiomyocytes on negatively charged poly(sodium p-styrene sulfonate) hydrogels, similar to their behavior on gelatin-coated polystyrene.

In this study, TyroSpheres were used to encapsulate adapalene, increasing its solubility and enhancing skin distribution while reducing irritancy compared to a commercial formulation, indicating promise for acne treatment in ex vivo and in vitro settings.

This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.

Milk-derived vesicles are promising for delivering drugs orally and treating various conditions.

In this study, researchers developed vegan exosome-like vesicles from microalgae that mimic mammalian exosomes, demonstrating promising in vitro, ex vivo, and clinical effects such as improved wrinkle depth and elasticity, making them a potential alternative in cosmetic applications.