Silk Fibroin-Based Nanoparticles Blended Fluoridated Hydrogel with Photodynamic Antibacterial for Infected Wound Healing

The study presents an innovative approach for treating wound infections by combining photodynamic therapy (PDT) with a novel hydrogel composed of organic semiconductor nanoparticles (OSN), silk fibroin (SF), perfluorosulfonic acid (PFSA), and agar. This hydrogel offers multiple benefits, including reduced secondary damage, enhanced antibacterial mechanisms, and improved moisturization and biocompatibility. Silk fibroin induces macrophage aggregation, while PDT activates these immune cells. PFSA provides moisturizing and porous properties. Both in vivo and in vitro tests confirm the hydrogel's efficacy in eliminating bacteria, and mouse model studies show significant improvements in wound healing and hair follicle regeneration. This hydrogel dressing holds promise as an advanced wound care solution with potential for promoting hair follicle regeneration and effective sterilization.