Low-Intensity Ultrasound Protects Human Scalp Hair Follicles From Taxane-Induced Toxicity
low-intensity ultrasound LIUS taxane paclitaxel PTX alopecia anagen VI scalp hair follicles HFs apoptosis mitosis micronucleated nuclei DNA damage hair matrix keratinocytes proliferation mitotic catastrophe melanin clumps chemotherapy-induced HF dystrophy hair bulbs microtubule bundles HF epithelial stem cells scalp cooling caps ultrasound chemotherapy hair loss hair follicles cell death cell division hair cells hair growth cell catastrophe hair damage hair roots stem cells cooling caps
Studysummary This study provides ex vivo proof-of-principle that low-intensity ultrasound may protect human hair follicles from paclitaxel-induced damage, potentially reducing chemotherapy-related alopecia.
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