April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”
This study provides ex vivo proof-of-principle that low-intensity ultrasound may protect human hairfollicles from paclitaxel-induced damage, potentially reducing chemotherapy-related alopecia.
In this pilot study, researchers found that ex vivo treatment with topical melatonin reduced chemotherapy-induced apoptosis and DNA damage in hairfollicle stem cells of human scalp cultures, suggesting melatonin's potential as a protective agent against taxane-induced permanent hair loss.
April 2023 in “Journal of Investigative Dermatology”
This pilot study suggests that topical melatonin may protect hairfollicle stem cells from paclitaxel-induced damage, potentially preventing chemotherapy-induced alopecia and enhancing the effects of scalp cooling caps.
Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hairfollicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.
PP405 is considered as a potential hair regrowth treatment, but users are skeptical due to past product failures. They compare it to Minoxidil and Finasteride, questioning its effectiveness and the intentions of pharmaceutical companies.
Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.
A 36-year-old man shared his 1.25-year progress using oral finasteride, oral minoxidil, RU58841, microneedling, nizoral, and LLLT for hair regrowth. He is thrilled with the results and considering a hair transplant for increased density.
How does folic acid support hair follicle health and growth at a cellular level?Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.
How does capsicum improve scalp circulation and boost growth?Capsaicin dilates blood vessels through TRPV1 activation, so capsicum is expected to raise scalp blood flow, but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.