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GlossaryTaxanes

chemotherapy drugs that disrupt cell division by stabilizing microtubules

Taxanes are a class of chemotherapy drugs that work by disrupting the normal function of microtubules, which are essential for cell division. By stabilizing these structures, taxanes prevent cancer cells from dividing and growing, making them effective in treating various types of cancer. However, they can also cause side effects like hair loss (alopecia) due to their impact on rapidly dividing cells in the body.

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research Dermatological Adverse Events with Taxane Chemotherapy

141 citations , September 2016 in “European Journal of Dermatology”

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

research CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia

58 citations , September 2019 in “EMBO Molecular Medicine”

CDK4/6 inhibitors can protect hair cells from chemotherapy damage.

Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

research Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

31 citations , March 2017 in “Journal of The American Academy of Dermatology”

Some breast cancer patients developed permanent hair loss after chemotherapy and hormonal therapy, showing patterns similar to common baldness and alopecia areata.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

19 citations , November 2018 in “Nutrients”

Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.

research Low Intensity Ultrasound as an Antidote to Taxane/Paclitaxel-Induced Cytotoxicity

11 citations , January 2022 in “Journal of Cancer”

Low intensity ultrasound may reduce side effects of chemotherapy drugs like paclitaxel.

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