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    Glossary Taxanes

    chemotherapy drugs that disrupt cell division by stabilizing microtubules

    Taxanes are a class of chemotherapy drugs that work by disrupting the normal function of microtubules, which are essential for cell division. By stabilizing these structures, taxanes prevent cancer cells from dividing and growing, making them effective in treating various types of cancer. However, they can also cause side effects like hair loss (alopecia) due to their impact on rapidly dividing cells in the body.

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    Research 30 of 415

    1. Dermatological adverse events with taxane chemotherapy European Journal of Dermatology · 2016 · 141 citations
    2. CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane‐induced alopecia EMBO Molecular Medicine · 2019 · 58 citations
    3. Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients Journal of The American Academy of Dermatology · 2017 · 31 citations
    4. Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation Nutrients · 2018 · 19 citations
    5. Low Intensity Ultrasound as an Antidote to Taxane/Paclitaxel-induced Cytotoxicity Journal of Cancer · 2022 · 11 citations
    6. Madarosis: a qualitative study to assess perceptions and experience of Australian patients with early breast cancer treated with taxane-based chemotherapy Supportive care in cancer · 2017 · 11 citations
    7. Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity Journal of Investigative Dermatology · 2023 · 7 citations
    8. Taxane-induced alopecia: A historical review of patients with ovarian or breast cancer treated with with paclitaxel, docetaxel or paclitaxel poliglumex Journal of Clinical Oncology · 2005 · 5 citations
    9. Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer Cureus · 2018 · 3 citations
    10. Permanent Alopecia in Breast Cancer Patients: Role of Taxanes and Endocrine Therapies Cutis · 2021 · 2 citations
    11. 1400 Low-intensity ultrasound protects human scalp hair follicles from taxane-induced toxicity 2023
    12. 506 Taxane chemotherapy promotes aging of human hair follicles and their stem cells Journal of Investigative Dermatology · 2024
    13. 803 Taxane chemotherapy induces epigenetic changes and premature senescence in human scalp hair follicles Journal of Investigative Dermatology · 2024
    14. Safety, tolerability, and PK of topical calcitriol formulation for treatment of chemotherapy-induced alopecia (CIA) in patients receiving taxane-based regimen: Final results. Journal of clinical oncology · 2019
    15. Mechanism-Based Strategies for Prevention of Taxane-Induced Hair Follicle Damage in Cancer Chemotherapy Cancers · 2026
    16. Assessment of long-term alopecia after adjuvant taxane therapy for early breast cancer: a cross-sectional survey Supportive Care in Cancer · 2025 · 1 citations
    17. Chemotherapy-related adverse effects with anthracycline and taxane-containing regimens in patients with localized Breast cancer: a descriptive study BMC Cancer · 2024 · 5 citations
    18. Anlotinib or Bevacizumab Combined with Taxane/Capecitabine for the Second-Line or Subsequent Treatment of HER-2 Negative Metastatic Breast Cancer: A Retrospective Cohort Study Drug Design Development and Therapy · 2025
    19. Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer Cancer Chemotherapy and Pharmacology · 2012 · 9 citations
    20. Safety and efficacy of low-dose metronomic cyclophosphamide plus vinorelbine in patients with metastatic breast cancer previously treated with anthracyclines and taxanes. Journal of Clinical Oncology · 2018
    21. Use of chemotherapy during human pregnancy Lancet Oncology · 2004 · 724 citations
    22. Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study ˜The œoncologist · 2018 · 59 citations
    23. Mucocutaneous side effects of antineoplastic chemotherapy Expert opinion on drug safety · 2004 · 55 citations
    24. Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia JAMA Dermatology · 2019 · 43 citations
    25. Management of Chemotherapy-Induced Alopecia With Scalp Cooling Journal of oncology practice · 2018 · 25 citations
    26. Hair safe study: Effects of scalp cooling on hair preservation and hair regrowth in breast cancer patients receiving chemotherapy - A prospective interventional study The Breast · 2022 · 6 citations
    27. The financial burden of scalp cooling therapy: A nonprofit organization data analysis Journal of the American Academy of Dermatology · 2024 · 4 citations
    28. Care for alopecia during chemotherapy of cancer patients Korean Journal of Clinical Oncology · 2011 · 3 citations
    29. Topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia (CIA): Efficacy findings from a phase I safety study. Journal of Clinical Oncology · 2016 · 2 citations
    30. Drug-induced scarring and permanent alopecia JAAD reviews. · 2024 · 2 citations