Alopecia Due to Chemotherapeutics, Hedgehog Inhibitors, Targeted Antibody Therapies, and Immune Checkpoint Inhibitors

    May 2024 in “ Deleted Journal ”
    Michael Max Sachse, Katharina C. Kähler
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    TLDR Cancer treatments can cause hair loss, but it is often reversible and can be managed with scalp cooling and support.
    The document reviews the causes, symptoms, diagnosis, and prevention of alopecia due to various cancer treatments. Chemotherapy-induced alopecia (CIA) affects up to 65% of patients, typically causing anagen effluvium within 1-3 weeks of treatment, which is usually reversible. Hedgehog inhibitors like vismodegib or sonidegib cause alopecia in up to 60% of cases, presenting as telogen effluvium. BRAF and immune checkpoint inhibitors are less commonly associated with hair loss. Scalp cooling can mitigate severe CIA in taxane-based chemotherapy. Early involvement with support groups and timely prescriptions for wigs are advised for those anticipating CIA or other treatment-related alopecia.
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