Color Doppler Ultrasound Pattern of Cutaneous Exosomes at High and Ultra-High Frequency

    July 2025 in “ PubMed
    Ximena Wortsman, Natacha Quezada
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    TLDR Exosome treatments may cause mild inflammation, new blood vessel growth, and hair growth, detectable by ultrasound.
    This case series investigates the ultrasound changes in cutaneous layers following exosome procedures, using high (24 MHz) and ultra-high (71 MHz) frequency ultrasound. Three cases were studied before and 3 months after the exosome application, comparing treated areas with non-treated areas. The study found consistent patterns of hyperechoic islets in the upper hypodermis and increased dermal vascularity, suggesting mild inflammation and neoangiogenesis. Notably, in one patient with alopecia, hair follicle growth was observed in the exosome-treated area. These findings highlight the potential of using ultrasonographic patterns to differentiate exosome-induced changes from dermatologic abnormalities and to objectively monitor anatomical changes. Further research is needed to assess the long-term persistence of these changes and the effects of local trauma.
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