Topical Delivery of Meropenem via Spanlastic Carbopol Gel: In-Vitro Studies and In-Vivo Application in Pressure Ulcers

September 2025 in “ Frontiers in Pharmacology ”

Sherif A. Abdel‐Fattah, Fatma M. Mady, Hatem A. Sarhan, Hazim O. Khalifa, Hamada Hashem, Hesham Hassan, Abdullah Alkhammash, Safy Hadiya, Reham Ali Ibrahem, Milad Reda Qelliny

Studysummary This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.

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