Unleashing the Potential of Spanlastics as Drug Delivery Carrier

Spanlastics are a promising vesicular drug delivery system that addresses the limitations of traditional drug administration by using non-ionic surfactants and edge activators to enhance deformability, stability, and encapsulation efficiency. This review highlights their superior efficacy in penetrating biological membranes compared to other nanocarriers like liposomes and niosomes. It discusses various preparation methods, characterization parameters, and formulation factors that affect their properties. Spanlastics have potential applications in oral, transdermal, intranasal, and ophthalmic drug delivery systems, with the potential to revolutionize targeted drug delivery.