Development and Characterization of In Situ Gelling Nasal Cilostazol Spanlastics

January 2025 in “ Gels ”

Maryana Salamah, Mária Budai-Szűcs, Bence Sipos, Balázs Volk, Gábor Katona, György Tibor Balogh, Ildikó Csóka

cilostazol spanlastics Phytagel Poloxamer-407 chitosan mucoadhesive properties

TLDR The developed nasal gel improves cilostazol delivery to the brain, enhancing its effectiveness and reducing side effects.

The study developed cilostazol-loaded spanlastics for nose-to-brain delivery to enhance cilostazol's solubility, absorption, and bioavailability while minimizing adverse effects. The formulations, incorporated into Phytagel®, Poloxamer-407, and chitosan gel bases, showed high encapsulation efficiency (>99%), suitable nasal droplet size, and improved cilostazol flux and permeability in vitro. The drug-release study indicated nearly complete release within 2 hours, suggesting improved bioavailability for cerebrovascular treatment. The optimal formulation, CIL-SPA1, demonstrated a Z-average suitable for brain targeting, high stability, and effective mucoadhesion, highlighting its potential for efficient central nervous system drug delivery.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Spanlastic-Laden Nanogel for Dermal Delivery of Bimatoprost in Androgenic Alopecia

March 2024 in “International journal of pharmaceutics. X”

Spanlastic-laden nanogel could be a better way to deliver hair growth medication through the skin for treating hair loss.

research Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity Against H-1975 Cell Lines

21 citations , March 2022 in “Pharmaceuticals”

The new Brigatinib nanocarrier is more effective against lung cancer cells than the free drug.

Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

research Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

19 citations , September 2020 in “Pharmaceutics”

Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.

Similar Research

5 / 50 results

research Formulation of Deformable Liponiosomal Hybrid of Repaglinide: In Vitro Characterization and Evaluation of the Anti-Diabetic Effect

3 citations , December 2023 in “International Journal of Nanomedicine”

Repaglinide-loaded liponiosomal hybrids improve blood sugar control and insulin release better than regular Repaglinide.

research Impact of Formulation Variables on Meloxicam Spanlastics Preparation

3 citations , December 2024 in “Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)”

Spanlastics are effective for delivering Meloxicam with improved stability and targeting.

research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations , April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

research The Effect of Cilostazol on Hair Growth: A Novel Therapeutic Option for the Treatment of Hair Loss

1 citations , April 2017 in “Journal of Investigative Dermatology”

Cilostazol may help hair grow and could be a new treatment for hair loss.

research Adverse Dermatologic Effects of Cardiovascular Drug Therapy: Part III

15 citations , November 2002 in “Cardiology in Review”

Cardiovascular drugs can cause various skin problems, so recognizing these reactions is important.