Development and Characterization of In Situ Gelling Nasal Cilostazol Spanlastics

January 2025 in “ Gels ”

Maryana Salamah, Mária Budai-Szűcs, Bence Sipos, Balázs Volk, Gábor Katona, György Tibor Balogh, Ildikó Csóka

cilostazol spanlastics Phytagel Poloxamer-407 chitosan mucoadhesive properties

Studysummary This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.

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