Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity Against H-1975 Cell Lines
March 2022
in “
Pharmaceuticals
”
TLDR The new Brigatinib nanocarrier is more effective against lung cancer cells than the free drug.
The study developed Brigatinib-loaded nanospanlastics (BGT-loaded NSPs) optimized for vesicle size, zeta potential, and entrapment efficiency, with the optimal formula (S13) achieving an entrapment efficiency of 81.58%, vesicle size of 386.55 nm, and zeta potential of -29.51 mV. The nanospanlastics were coated with chitosan and demonstrated complete drug encapsulation, high stability over three months, and improved drug release compared to free Brigatinib. The cytotoxic activity against H-1975 lung cancer cell lines was enhanced threefold compared to the free drug, suggesting that BGT-loaded NSPs could be an effective nanocarrier for enhancing Brigatinib's anticancer efficacy.
