Dynamic Evaluation of Pathological Changes in a Mouse Acne Model by Optical Imaging Technology

May 2023 in “ Experimental dermatology ”

Dongying Li, Yanan Sun, Xiaohan Ren, Na Zhou, Lu Li, Gaiying He, Shuhua Ma, Yi Wang

Propionibacterium acnes epidermal thickening follicular keratosis sebaceous gland hyperplasia inflammation abscess formation optical imaging anti-acne treatments P. acnes skin thickening keratosis sebaceous gland enlargement swelling pus formation imaging technology acne treatments

TLDR New imaging techniques can assess and track changes in mouse acne without harm, aiding treatment choices.

This study used a mouse acne model to dynamically evaluate pathological changes with nondestructive optical imaging techniques. It found that Propionibacterium acnes colonization peaked on day 1 and decreased by day 7, with inflammation subsiding as bacteria were engulfed. The model showed significant epidermal thickening, abnormal follicular keratosis, and sebaceous gland hyperplasia. Inflammation was characterized by acute responses and abscess formation, with skin morphology returning to normal by day 13. The study demonstrated the effectiveness of optical imaging in monitoring acne pathology and evaluating anti-acne treatments, highlighting the importance of inflammation in acne development and reducing the number of animals required for research.

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