Novel Vegan Exosome-Like Biomimetic Vesicles for Skin and Hair Follicle Protection and Rejuvenation: Structural and Functional Characterization and Placebo-Controlled Clinical Efficacy Studies

    May 2026 in “ Cosmetics ”
    Noemí García-Delgado, Alexandre Lapeyre, Jordi Ayats
    Studysummary In this study, researchers developed vegan exosome-like vesicles from microalgae that mimic mammalian exosomes, demonstrating promising in vitro, ex vivo, and clinical effects such as improved wrinkle depth and elasticity, making them a potential alternative in cosmetic applications.
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    Research cited in this study 10

    1. Exosomes in Dermatology: Emerging Roles in Skin Health and Disease Pharmaceutics · 2025
    2. Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials? International Journal of Molecular Sciences · 2025
    3. Fibroblast-Derived Growth Factors and Exosomes as Cosmeceuticals Dermatological reviews · 2023
    4. Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders Cells · 2023
    5. Exosomes: The Latest in Regenerative Aesthetics Regenerative Medicine · 2023
    6. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    7. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    8. Activated Hair Follicle Stem Cells and Wnt/β-Catenin Signaling Involved in Pathogenesis of Sebaceous Neoplasms International Journal of Medical Sciences · 2014
    9. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    10. Hair Cycle-Specific Expression of Versican in Human Hair Follicles Journal of Dermatological Science · 2005