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Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Finasteride effectively blocks enzyme causing male pattern baldness.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Compound 4 is a promising treatment for hair loss with low toxicity.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Finasteride affects SRD5A2 gene pattern, possibly causing lasting side effects.

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Combining supplements with minoxidil improves hair growth more than minoxidil alone.

Liposomes and niosomes improve finasteride delivery for hair loss treatment.

Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Finasteride exposure harms tadpole reproduction and hormone balance.

Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.