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GlossaryCRISPR-associated protein

enzyme that cuts DNA at specific locations for gene editing

A CRISPR-associated protein, often abbreviated as Cas protein, is an enzyme that plays a crucial role in the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system, which is a natural defense mechanism found in bacteria and archaea. These proteins, such as Cas9, act like molecular scissors that can precisely cut DNA at specific locations, making them powerful tools for gene editing in research and medicine.

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research Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy

47 citations , February 2020 in “Biomaterials”

Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.

research Spatiotemporal control of CRISPR/Cas9 gene editing

51 citations , June 2021 in “Signal Transduction and Targeted Therapy”

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders

research Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders

November 2023 in “ACS Omega”

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for <i>In Vivo</i> CRISPR/Cas-Based Genome Editing

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

research Efficient Editing of CSLD2 Orthologue by CRISPR/Cas9 Affects Cell Morphogenesis of Root Hair in Spinach

1 citations , January 2022 in “Research Square (Research Square)”

CRISPR/Cas9 editing in spinach affects root hair growth by altering specific genes.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 4 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Maintaining hair until Breezula without Fin

in Treatment 6 upvotes 4 years ago

A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

community Why is nobody studying the difference between donor and balding hair?

in Chat 88 upvotes 2 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Had a son while being on FIN, MUST READ

in Finasteride/Dutasteride 615 upvotes 10 months ago

A user shared his experience of having two healthy children while continuously using finasteride (Fin) for hair loss, challenging fears about its potential impact on fetal development. The discussion that followed included various perspectives, with some users sharing similar experiences, others expressing concerns about potential risks, and some emphasizing the need for more substantial evidence before drawing conclusions.

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