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    Glossary CRISPR-associated protein

    enzyme that cuts DNA at specific locations for gene editing

    A CRISPR-associated protein, often abbreviated as Cas protein, is an enzyme that plays a crucial role in the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system, which is a natural defense mechanism found in bacteria and archaea. These proteins, such as Cas9, act like molecular scissors that can precisely cut DNA at specific locations, making them powerful tools for gene editing in research and medicine.

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    Research 30 of 681

    1. Innovations in Skin and Soft Tissue Aging—A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes Aesthetic Plastic Surgery · 2023 · 17 citations
    2. Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice bioRxiv (Cold Spring Harbor Laboratory) · 2018
    3. 545 Skin Organoids derived from NCSTN mutated patient-induced pluripotent stem cells recapitulate Hidradenitis Suppurativa pathogenic hallmarks 2022
    4. Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss EBioMedicine · 2020 · 19 citations
    5. 924 Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in iPS cells for recessive dystrophic epidermolysis bullosa Journal of Investigative Dermatology · 2019
    6. 547 CDK9 Kinase Activation in Association with AFF1-SEC Initiate Epidermal Progenitor differentiation Journal of Investigative Dermatology · 2022
    7. 237 Unveiling Skin Cancers Pathophysiology via the Modeling of Xeroderma Pigmentosum Disease Modeling Using CRISPR-Cas9 Technology Journal of Investigative Dermatology · 2024
    8. Development of Woolly Hair and Hairlessness in a CRISPR−Engineered Mutant Mouse Model with KRT71 Mutations Cells · 2023
    9. 875 A novel animal model of Desmoglein 1 (Dsg1) deficiency reveals an essential role for Dsg1 in epidermal barrier formation Journal of Investigative Dermatology · 2018
    10. Elucidating the roles of three β-glucuronosyltransferases (GLCATs) acting on arabinogalactan-proteins using a CRISPR-Cas9 multiplexing approach in Arabidopsis BMC plant biology · 2020 · 28 citations
    11. Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus 2019 · 3 citations
    12. 476 Development of an intrinsic skin sensor for blood glucose level with CRISPR-mediated genome editing in epidermal stem cells Journal of Investigative Dermatology · 2017
    13. Expression and tissue distribution analysis of vimentin and transthyretin proteins associated with coat colors in sheep (Ovis aries) Animal Bioscience · 2023
    14. CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen Genes · 2020 · 13 citations
    15. Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats 2023
    16. Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms Nature Communications · 2024 · 11 citations
    17. Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application Stem Cell Research & Therapy · 2020 · 53 citations
    18. Hutchinson-Gilford syndrome: History, causes, phenotype and research advances GSC Advanced Research and Reviews · 2023
    19. Non-viral delivery of the CRISPR/Cas system: DNA<i>versus</i>RNA<i>versus</i>RNP Biomaterials Science · 2022 · 21 citations
    20. Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions Molecular Human Reproduction · 2024 · 3 citations
    21. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    22. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    23. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019
    24. New developments in the molecular treatment of ichthyosis: review of the literature Orphanet journal of rare diseases · 2022 · 21 citations
    25. Two‐photon microscopy for intracutaneous imaging of stem cell activity in mice Experimental Dermatology · 2016 · 16 citations
    26. Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders ACS Omega · 2023
    27. Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats Animals · 2023 · 1 citations
    28. CRISPR/Cas9‐mediated loss of FGF5 function increases wool staple length in sheep ˜The œFEBS journal · 2017 · 47 citations
    29. Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity Frontiers in cell and developmental biology · 2023 · 7 citations
    30. Patients with Compound Heterozygous Mutations in Forkhead Box N1 have a Severe Immunodeficiency while Maintaining Normal Skin and Hair Development 2017