Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism

    July 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Yufei Han, Qian Zhuang, Binyong Sun … Ruobing Ren

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 7

    1. 5-Alpha-Reductase Type 2 Deficiency: Is There a Genotype-Phenotype Correlation? A Review Hormones · 2018
    2. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    3. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    4. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    5. Selective Non-Steroidal Inhibitors of 5α-Reductase Type 1 Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2004
    6. Clinical Application of 5α-Reductase Inhibitors Journal of endocrinological investigation · 2001
    7. Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1998