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In this study, researchers identified two distinct homozygous mutations in the KRT85 gene among consanguineous Pakistani families with pure hair and nail ectodermal dysplasia, highlighting variations in severity and potential impacts on the K85 protein function.

In this study, researchers identified distinct chromatin regions and regulatory elements that drive keratinocyte-specific gene expression, highlighting complex enhancer modules influencing skin epithelium through a combination of transcriptional activators and repressors.

This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.

This study suggests that adjusting the ratios of keratin-associated proteins to keratin intermediate filaments can create keratin/chitosan hydrogels with more consistent gel properties for tissue engineering.

This review discusses the genetic, autoinflammatory, and keratinization factors involved in hidradenitis suppurativa and presents the concept of classifying it as an autoinflammatory keratinization disease, but reports no new clinical results.

This study found that 70-MHz ultrasound can detect early signs of hidradenitis suppurativa linked to severity, including hair follicle abnormalities and keratin fragmentation, aiding in diagnosis and management.

This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.

This study found that men with Kennedy disease have a significantly lower risk of androgenetic alopecia, likely due to androgen receptor gene alterations from the disease's polyglutamine expansion.

This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.

This study described seven male patients and six female carriers of keratosis follicularis spinulosa decalvans, highlighting distinct dermatological and ophthalmic markers including follicular hyperkeratosis and corneal dystrophy.

This article reports on the use of ketoconazole for treating cutaneous leishmaniasis, but includes no new clinical trial findings.

This study found that human hair keratin coatings enhanced adhesion and proliferation of L929 mouse fibroblasts compared to uncoated and collagen type 1 surfaces, suggesting keratin's potential as a surface coating for cell cultures.

This study found that a microneedle array patch using a blend of kangfuxin, chitosan, and fucoidan significantly accelerated wound healing in rats by enhancing epithelial thickness and collagen deposition.

This review highlights the role of keratin mutations in epidermolysis bullosa simplex and the resulting chronic inflammation, but it presents no new experimental findings.

This study found that the mechanical stiffening of the human hair follicle along the first millimeter is linked to changes in the keratin network architecture and composition during keratinization.

This study found that cysteine supplementation significantly increases keratin expression in human keratinocytes, and counteracts the negative impact of iron deficiency on keratin production by enhancing iron availability for cellular processes.

This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.

This study found that selective deletion of Ctip2 in epidermal keratinocytes in adult mice leads to atopic dermatitis-like inflammation and suggests Ctip2 plays a crucial role in skin barrier maintenance and inflammatory regulation.

This study found that keratin K80, structurally similar to hair keratins, is broadly expressed in various epithelial tissues and is involved in intermediate filament formation with multiple type I partners.

This study reports that four Indian patients with acne keloidalis nuchae also exhibited acanthosis nigricans, suggesting a potential link to metabolic syndrome, though further research is needed to confirm this association.

This study suggests that an increase in kenogen phases, along with rising vellus hair cycles and fewer normal hair cycles, is associated with the progression of female androgenetic alopecia.

In this study, molecular dynamics simulations indicated that the Glu413Lys mutation in human hair keratin significantly affects the stability of coiled coil structures, whereas Glu413Asp showed no impact on stability.

This review discusses the widespread use of Brazilian keratin treatments and notes that many contain formaldehyde, marketed as safe despite potential safety concerns, but reports no new clinical results.

This review found topical ketoconazole to be highly effective against Malassezia-related skin conditions, though other treatments may outperform it for Tinea and Candida infections.

This study found that Schistosoma mansoni cercariae stimulate epidermal keratinocytes in mice, initiating pro-inflammatory responses and barrier repair mechanisms akin to those in wound healing.

Raspberry ketone may help grow hair and improve skin elasticity.

This study found that the LEF-1 binding site acts as an enhancer element for the wool keratin intermediate filament gene promoter in hair follicle cortex, with specificity regulated by additional factors.

In this study, researchers identified two novel peptidylarginine deiminases from treated rat keratinocytes, both showing enzyme activity with PAD‐R11 reflecting a characteristic of epidermal enzymes.

This study found that human keratinocytes' sensitivity and response to vitamin D3 analogues vary based on cell density, serum availability, and calcium concentration.

This study observed that surfactants in cosmetic treatments can bind to keratinous tissues like hair and nails, affecting their tensile properties and possibly leading to deterioration depending on the specific detergents used.