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The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.

This study provides evidence supporting a regulatory relationship between the transcriptional regulator Hoxc13 and Krtap16 genes, which are crucial for proper hair growth in mice.

This study observed that targeted expression of the neu oncogene in transgenic mice led to significant epidermal hyperplasia and a carcinoma-like appearance, suggesting a crucial role for erbB2 signaling in epidermal proliferation and carcinogenesis.

This study found that nuclear beta-catenin, LEF1, and PHLDA1 expression was conserved in matrical tumors, suggesting a shared tumorigenesis process involving Wnt pathway activation.

Terrestrial vertebrates have balanced keratin gene clusters, unlike teleost fish.

This study found that hydroquinone caused structural damage to the skin of rats, while aloe vera reduced this damage, suggesting potential concerns for its use in skin lightening creams.

This study found that keratin 19, unlike keratin 14, forms less stable filaments with keratin 5, suggesting distinct assembly properties and potential unique roles in skin basal cells.

In this study, ketoconazole treatment improved acne in all women and reduced hirsutism in some, but it caused several side effects and requires careful monitoring.

This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.

This study suggests that the mechanical robustness of hair may be enhanced by the binding interactions of keratin-associated proteins, particularly KAP8.1, with intermediate filament proteins.

In this study, engineered skin substitutes containing murine dermal papilla cells developed hair follicle-like structures when grafted onto mice, suggesting a model for generating chimeric hair.

This study found that K15 is variably expressed in sheep and mouse hair follicles, with specific patterns suggesting a role in the early stages of keratinocyte differentiation.

Targeted therapies promoting differentiation could help treat basal cell carcinoma by exhausting cancer stem cells.

This study identified a mutation in the keratin 71 gene that causes curly hair in certain rats, advancing our understanding of hair formation.

This study demonstrated that hair follicle bulge stem cells can form epidermis in a tissue-engineered skin model, highlighting the significance of K5/K17 filaments in slow-cycling stem cell subsets.

This study seeks to clarify the terminology and classification of keratoacanthoma and similar squamous cell carcinoma lesions with central keratin-filled craters to aid in accurate differential diagnosis.

This study identified KLHL24 as a new gene linked to a subtype of epidermolysis bullosa simplex, highlighting its role in unresolved cases by involving a degradation-resistant truncated protein impacting keratin turnover.

This review covers various disorders of cornification and their treatments, offering clinical insights but reporting no new research findings.

This study found that regulatory sequences crucial for inducing K6a expression in response to epidermal injury are located in specific upstream regions of the K6a gene in transgenic mice.

This study found that keratin 15 expressing cells from the hair follicle contribute to the development and long-term persistence of cutaneous papillomas in transgenic mice, with a subset showing the Ha-ras mutation.

This study explains how the development of keratin-associated proteins in embryonic epidermis is crucial for forming protective barriers in vertebrates, enabling them to adapt to terrestrial environments.

This article presents two cases of tinea capitis in postpubertal individuals highlighting the importance of early treatment to prevent scarring and permanent hair loss; it reports no new clinical results.

This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.

In this study, researchers found that contrary to expectations, keratin 10 domains did not reduce cell proliferation and instead increased tumor development in genetically modified mice.

This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.

This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.

This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.

This study found that thyroid hormones T3 and T4 enhance keratin 15 promoter activity and stimulate CD200 expression in epithelial stem cells from human scalp hair follicles, affecting their growth and differentiation.