TLDR Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.
The study investigated the role of keratin 15+ cells from hair follicles in the development of skin tumors using a transgenic mouse model. It was found that these cells significantly contributed to the formation of papillomas within 20 weeks of promotion. Unlike their transient role in skin wound healing, keratin 15 progeny persisted in papillomas and some malignancies for extended periods. Additionally, the study revealed heterogeneity in papillomas, with about 30% of keratin 15-derived regions expressing the Ha-ras mutation. These findings indicated that keratin 15 expressing cells from hair follicles played a crucial role in the development and persistence of cutaneous papillomas, with some expressing mutations typical of cancer initiation.
49 citations
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October 2009 in “Cancer research” Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.
141 citations
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May 2007 in “Cancer Research” CD34 is crucial for skin tumor development in mice.
207 citations
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July 2006 in “Development” MTS24 marks a new type of skin cell that helps hair growth and repair.
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November 2005 in “Nature Medicine” 561 citations
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April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
153 citations
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April 1998 in “Current Biology” The risk of skin tumors becoming malignant depends on the specific skin cell type affected.
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July 2008 in “British Journal of Dermatology” 138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
