TLDR Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.
The study used Krt1‐15CrePR1;R26R transgenic mice to investigate the role of keratin 15+ cells from hair follicles in skin tumor development, specifically squamous papillomas. It was observed that keratin 15 expressing cells contributed to most papillomas within 20 weeks of promotion and persisted in these tumors for months, unlike their transient role in wound healing. Additionally, papillomas exhibited cellular heterogeneity and about 30% of keratin 15-derived regions expressed the codon 61 Ha-ras mutation, indicating that these cells played a significant role in the development and persistence of cutaneous papillomas, with some expressing mutations typical of initiated cancer cells.
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
