TLDR Human hair keratins improve cell adhesion and growth on culture surfaces.
The study investigated the use of human hair keratins as a bioactive coating for in vitro cell culture, focusing on their adsorption onto tissue culture polystyrene surfaces. The research characterized keratin density, nano-topography, and hydrophobicity, finding that keratins could be deposited up to a density of 650 ng/cm² with a coating concentration of 80 μg/ml or higher. Murine L929 fibroblasts cultured on these keratin-coated surfaces showed improved adhesion, proliferation, and fibronectin expression compared to uncoated and collagen type 1 coated surfaces. These findings suggested that human hair keratins could serve as an effective surface coating material to enhance cell culture substrate compliance.
143 citations
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January 2012 in “Cell and Tissue Research” 47 citations
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September 2011 in “Acta biomaterialia” Protein composition greatly affects the function of keratin biomaterials.
53 citations
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July 2011 in “Biomaterials” Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.
177 citations
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April 2008 in “Biomedical Materials” Human hair proteins can be used to create scaffolds that support cell growth for tissue engineering.
309 citations
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October 2007 in “Biomaterials” Keratin from human hair helps nerves heal faster.
272 citations
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September 2001 in “Journal of Biological Chemistry” Human hair keratins were cataloged, showing their roles in hair differentiation stages.
235 citations
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July 1999 in “Journal of biological chemistry/The Journal of biological chemistry” Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.
Human hair keratins can self-assemble and support cell growth, useful for biomedical applications.
Keratin hydrogels from human hair show promise for tissue engineering and regenerative medicine.
Human hair keratins can be turned into useful 3D biomedical scaffolds through a freeze-thaw process.
1 citations
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August 2024 in “Polymers” Bacterial cellulose is a promising material for biomedical uses but needs improvements in antimicrobial properties and degradation rate.
23 citations
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January 2015 in “Stem cells international” Coating surfaces with human hair keratin improves the growth and consistency of important stem cells for medical use.
