January 2016 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that the IGF2 gene Apa1 A820G polymorphism is associated with an increased risk of developing PCOS in the studied population.
January 2016 in “International Journal of Reproduction Contraception Obstetrics and Gynecology” This study found that insulin resistance varies across different PCOS phenotypes, with the PCOM+MI+HA phenotype showing higher resistance than others.
December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.
January 2015 in “International Journal of Research in Medical Sciences” This case report is the first to associate HAIR-AN syndrome with polycystic ovaries, Hashimoto’s thyroiditis, and several metabolic conditions in a 21-year-old woman, emphasizing early diagnosis and management.
October 2014 in “Journal of Nutrition & Food Sciences” This study found that in visceral-obese Korean adults, hair chromium and selenium levels were inversely associated with insulin resistance, while copper levels showed a positive association.
August 2013 in “Fertility and sterility” This study suggests that metformin might serve as a diagnostic and therapeutic option to distinguish insulin resistance-related ovarian testosterone excess from a testosterone-secreting tumor in women with virilization.
March 2013 in “Journal of pediatric nursing” This case report presents a 14-year-old girl with type A insulin resistance, illustrating diagnostic processes to differentiate it from type 2 diabetes in the context of pediatric obesity and hyperglycemia.
February 2013 in “Journal of The American Academy of Dermatology” There is no significant link between insulin resistance and certain hair disorders like idiopathic hirsutism and androgenic alopecia.
January 2013 in “China Animal Husbandry & Veterinary Medicine” This study found that IGFBP-5 may play a significant regulatory role in the hair follicle development of Inner Mongolia Cashmere goats, with more consistent expression patterns across different stages.
October 2012 in “Journal of Dermatological Science” Erythropoietin can promote hair growth by increasing IGF-1 in hair cells.
February 2010 in “Journal of The American Academy of Dermatology” This study found that nonobese women with idiopathic hirsutism had higher fibrinogen levels and lower nitrite/nitrate concentrations compared to controls, similar to those with PCOS.
January 2010 in “The Year book of dermatology” Taking metformin with intense pulsed light therapy improves hair removal for women with PCOS.
January 2010 in “Ciencia UANL” This study found a significant relationship between androgenetic alopecia and insulin resistance-associated indicators like obesity in young men, suggesting a potential risk for developing cardiovascular and metabolic disorders.
January 2005 in “Elsevier eBooks” This paper discusses the relationship between insulin resistance and polycystic ovarian syndrome, noting that when they coexist, they amplify androgen secretion and skin-related changes, affecting ovulation and fertility, but presents no new experimental findings.
November 2004 in “John Wiley & Sons, Ltd eBooks” This chapter reviews polycystic ovary syndrome (PCOS), focusing on its definition, causes, and treatment approaches, but reports no new research findings.
January 2000 in “Journal watch” This study from Finland suggests that insulin resistance might be the connecting factor between early-onset androgenetic alopecia and coronary artery disease in men under 35.
This study reported that women with acanthosis nigricans and insulin resistance often exhibit signs of hyperandrogenism, including hirsutism, and have elevated fasting plasma insulin compared to controls.
February 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found that male patients with Androgenetic alopecia have higher serum leptin, lower vitamin D levels, and an altered adiponectin/leptin ratio, which may contribute to the disease's pathogenesis.
March 2022 in “Benha Journal of Applied Sciences” This study found that serum PGRN levels and HOMA-IR were significantly higher in male AGA patients compared to controls, suggesting a link to insulin resistance and metabolic syndrome.
September 2020 in “Benha Journal of Applied Sciences” In this study, researchers found that serum Myostatin levels and HOMA-IR were significantly higher in patients with androgenic alopecia compared to controls, suggesting they could be indicators of disease susceptibility and severity.
February 2020 in “Benha Journal of Applied Sciences” This study found that higher levels of Galectin-3 and HOMA-IR are independent predictors of androgenetic alopecia severity in both male and female patients.
January 2020 in “Menoufia Medical Journal” This study found that the expression of IGF-1 receptor was significantly reduced in women with female androgenetic alopecia compared to healthy controls.
April 2018 in “Journal of Investigative Dermatology” This study found that 1550-nm Er:Glass fractional laser treatment significantly increased hair density and shaft diameter in patients with androgenetic alopecia, though the mechanism may not involve Wnt10A or IGF-1 expression.
February 2017 in “Clinical dermatology open access journal” This study found a strong association between insulin resistance and early androgenetic alopecia in males, with insulin resistance increasing alongside alopecia severity and influenced by factors like smoking.
January 2017 in “IP Indian journal of clinical and experimental dermatology” This study found that metabolic syndrome was significantly more common in men with early-onset androgenetic alopecia compared to controls, indicating a potential increased risk of cardiovascular issues in this population.
January 2016 in “Indian journal of clinical and experimental dermatology” This study reported that young males with early onset androgenetic alopecia had higher testosterone levels, but did not show a significant difference in insulin resistance or metabolic syndrome compared to controls.
This study reported no significant statistical difference in insulin resistance or QUICKI levels between reproductive women with androgenetic alopecia and age-matched controls.
May 2015 in “Endocrine Abstracts” Both finasteride and metformin effectively treat PCOS by reducing hormone levels and insulin resistance.
November 2001 in “Hair transplant forum international” This article discusses public health science and general practice without presenting new research findings.
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March 1996 in “Journal of Investigative Dermatology” Increased IGF-1R expression is linked to thicker skin growth.