Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome with PCOS and Hashimoto's Thyroiditis: Case Report

    January 2015 in “ International Journal of Research in Medical Sciences ”
    Amarnath Kulkarni, Shashank Kumar Srivastav, Saraswathi Susarla, Usha Kulkarni, Chaya A. Kumar, Sunita Chikkala, Sheik Majeeda Tabassum
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    TLDR A patient with HAIR-AN syndrome, PCOS, and Hashimoto's thyroiditis improved with early diagnosis and treatment to prevent serious health problems.
    In 2015, a case study was conducted on a 21-year-old female patient who presented with hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndrome, polycystic ovary syndrome (PCOS), Hashimoto's thyroiditis, hypertension, type-II diabetes mellitus, and dyslipidemia. The patient had a history of hypothyroidism for 4 years and secondary amenorrhea for 3 years. She was obese with a BMI of 40.08 and severe hirsutism. Test results showed elevated testosterone levels and imaging studies revealed an enlarged right adrenal gland, hepatomegaly with fatty infiltration of grade-1, and bilateral polycystic ovaries. The patient was treated with metformin, spironolactone, atorvastatin, telmisartan, and eltroxin for hypothyroidism. This case highlighted the importance of early diagnosis and management of HAIR-AN Syndrome with PCOS and Hashimoto’s thyroiditis to prevent long-term health issues such as cardiovascular disease and endometrial cancer.
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