Comparison of Mathematical Indices of Insulin Resistance for Clinical Application in the Four Phenotypes of Polycystic Ovarian Syndrome

The study assessed insulin resistance in 60 newly diagnosed PCOS participants using the mathematical indices HOMA and QUICKI, across four phenotypes of PCOS. It found significant differences in insulin resistance among the phenotypes, with the PCOM+MI+HA phenotype showing the highest resistance. The study concluded that insulin resistance was not universal across all PCOS phenotypes, and that simple mathematical indices could be used in clinical settings to identify individuals with insulin resistance, allowing for early intervention to prevent long-term metabolic issues. The study emphasized the need for cut-off values that consider all factors influencing insulin sensitivity.