Prevalence of Metabolic Syndrome in the Family Members of Women with Polycystic Ovary Syndrome from North India

    January 2014 in “ Indian Journal of Endocrinology and Metabolism ”
    Iram Shabir, Mohd Ashraf Ganie, Mohammad Afzal Zargar, Dilafroz Bhat, Mohammad Muzaffar Mir, Aleem Jan, Zaffar Amin Shah, Vicar Jan, Riyaz Rasool, Andleeb Naqati
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    TLDR Family members of North Indian women with PCOS have a high rate of metabolic syndrome.
    The study conducted on 37 North Indian women with polycystic ovary syndrome (PCOS) and their first-degree relatives between January 2009 and May 2010 found a high prevalence of metabolic syndrome (MS) among the family members. Using the International Diabetes Federation (IDF) criteria, MS was detected in 27% of the women with PCOS, 85% of their mothers, 65% of their fathers, 19% of their sisters, and 6% of their brothers. According to the Adult Treatment Panel III (ATP III) criteria, the prevalence was 22% in women with PCOS, 80% in mothers, 56% in fathers, and 25% in sisters, with no cases in brothers. Dyslipidemia was the most common metabolic abnormality, and hyperandrogenism, such as premature balding, was observed in 73.7% of brothers and 73.9% of fathers. The study concluded that MS and its components are prevalent in the family members of women with PCOS, suggesting a genetic susceptibility and the need for further research and preventive measures.
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