Increased Frequency of the DI Genotype of the Angiotensin-I Converting Enzyme and Association of the II Genotype with Insulin Resistance in Polycystic Ovary Syndrome

    January 2012 in “ European Journal of Endocrinology ”
    Vasiliki Koika, Neoklis A. Georgopoulos, Athanasia Piouka, Nikolaos D. Roupas, Anastasia Karela, Anastasia Armeni, Eleni Katsantoni, Dimitrios Panidis
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    TLDR The study suggests certain ACE gene variations are more common in women with PCOS and may be linked to increased insulin resistance.
    The study examined the relationship between the angiotensin I converting enzyme (ACE) gene I/D polymorphism and polycystic ovary syndrome (PCOS) as well as insulin resistance (IR) in 801 women with PCOS and 266 healthy controls. It found a significantly higher frequency of the DI genotype in women with PCOS, especially in those with hyperandrogenism (Groups A and B), and a positive correlation between the II genotype and markers of insulin resistance. The II genotype was also associated with higher fasting insulin levels and a lower glucose/insulin ratio in PCOS women with hyperandrogenism. The study suggests that the ACE I/D polymorphism may contribute to the pathogenesis of PCOS, particularly in relation to hyperandrogenism and insulin resistance. No specific funding was received for this research.
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