Increased Frequency of the DI Genotype of the Angiotensin-I Converting Enzyme and Association of the II Genotype with Insulin Resistance in Polycystic Ovary Syndrome

The study examined the relationship between the angiotensin I converting enzyme (ACE) gene I/D polymorphism and polycystic ovary syndrome (PCOS) as well as insulin resistance (IR) in 801 women with PCOS and 266 healthy controls. It found a significantly higher frequency of the DI genotype in women with PCOS, especially in those with hyperandrogenism (Groups A and B), and a positive correlation between the II genotype and markers of insulin resistance. The II genotype was also associated with higher fasting insulin levels and a lower glucose/insulin ratio in PCOS women with hyperandrogenism. The study suggests that the ACE I/D polymorphism may contribute to the pathogenesis of PCOS, particularly in relation to hyperandrogenism and insulin resistance. No specific funding was received for this research.