The Hair Loss Encyclopedia

Serum Progranulin and Insulin Resistance Evaluation in Male Androgenetic Alopecia Patients

March 2022 in “ Benha Journal of Applied Sciences ”

Monib K.M., Hussein M.S., Ahmad E.S., Ramadan F.A.

androgenetic alopecia serum progranulin insulin resistance HOMA-IR metabolic syndrome AGA PGRN IR MetS

TLDR AGA patients have higher insulin resistance and serum progranulin levels, suggesting a link to metabolic issues.

This study evaluated serum progranulin (PGRN) and insulin resistance (IR) in 60 male patients with androgenetic alopecia (AGA) compared to 20 healthy controls. The results showed that AGA patients had significantly higher levels of fasting insulin, HOMA-IR, and serum PGRN compared to the control group. The findings suggest that PGRN plays a critical role in contributing to IR and metabolic syndrome (MetS) in AGA patients. The study recommends close long-term follow-up and early detection of IR and MetS for better management of AGA.

View this study on bjas.journals.ekb.eg →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Androgenetic alopecia - I want your honest opinion

in Female 30 upvotes 1 year ago

A female user's diagnosis of androgenetic alopecia, and the advice shared in response which suggests taking spironolactone and minoxidil together to prevent hair loss.

community Opinions- AGA options and pregnancy

in Female 7 upvotes 2 months ago

A user with Androgenetic Alopecia is seeking advice on hair growth treatments while planning for pregnancy. Current routine includes LaserCap, Nizoral Shampoo, scalp massage, The Ordinary Multi Peptide Serum, vitamin D, prenatal vitamins, and SEEN shampoo.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

23 upvotes 7 years ago

Pumpkin seed oil may help hair growth in men with androgenetic alopecia. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Hope Medicine announces HMI-115 phase II clinical trial for androgenetic alopecia in China

in Research/Science 59 upvotes 1 year ago

Hope Medicine's announcement of the HMI-115 Phase II clinical trial for androgenetic alopecia in China; other related trials have been conducted or are ongoing in different countries, including Australia, US, and Europe. There is speculation that the product may be accepted across borders without additional testing.

Similar Research

5 / 1000+ results

research Adipokines in the Skin and Dermatological Diseases

31 citations, November 2020 in “International journal of molecular sciences”

Adipokines affect skin health and could be targeted for treating skin diseases.

Proteomics as a Tool to Improve Novel Insights into Skin Diseases: What We Know and Where We Should Be Going

research Proteomics as a Tool to Improve Novel Insights into Skin Diseases: What We Know and Where We Should Be Going

3 citations, October 2022 in “Frontiers in Surgery”

Proteomics combined with other technologies can lead to a better understanding of skin diseases.

Kin-Cohort Analysis of LRRK2-G2019S Penetrance in Parkinson's Disease

research Kin-Cohort Analysis of LRRK2-G2019S Penetrance in Parkinson's Disease

47 citations, June 2011 in “Movement Disorders”

The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.

A Preliminary Study of Finasteride in Tourette Syndrome

research A Preliminary Study of Finasteride in Tourette Syndrome

46 citations, September 2011 in “Movement Disorders”

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.

Desferrioxamine Treatment of Aceruloplasminemia: Long-Term Follow-Up

research Desferrioxamine Treatment of Aceruloplasminemia: Long-Term Follow-Up

39 citations, May 2011 in “Movement Disorders”

Finasteride may help reduce symptoms in male Tourette syndrome patients.