Association of Insulin-Like Growth Factor 2 Apa1 A820G Gene (rs680) Polymorphism with Polycystic Ovarian Syndrome
January 2016
in “
International journal of reproduction, contraception, obstetrics and gynecology
”
Studysummary This study found that the IGF2 gene Apa1 A820G polymorphism is associated with an increased risk of developing PCOS in the studied population.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study examined the relationship between the IGF2 Apa1 A820G gene polymorphism and polycystic ovarian syndrome (PCOS) in 204 women with PCOS and 204 healthy controls. It found a significant association, with the G allele being more frequent in the PCOS group and the GG genotype increasing the risk of PCOS. Women with the GG genotype also had higher BMI and insulin resistance. The study suggests that the IGF2 gene polymorphism could be a molecular marker for identifying women at risk of PCOS in the South Indian population.
