Association of Follicle-Stimulating Hormone Receptor Gene Ser680Asn (rs6166) Polymorphism with Polycystic Ovarian Syndrome

January 2016 in “ International journal of reproduction, contraception, obstetrics and gynecology ”

Sujatha Thathapudi, Jayashankar Erukkambattu, Uma Addepally, Kodati Vijayalakshmi, Qurratulain Hasan

follicle-stimulating hormone receptor FSHR Ser680Asn polymorphism polycystic ovarian syndrome PCOS A allele AA genotype body mass index BMI luteinizing hormone LH LH/FSH ratio GG genotype basal FSH levels insulin resistance FSH receptor FSH

TLDR A certain genetic variation is linked to a higher risk of polycystic ovarian syndrome.

The study examined the relationship between the Ser680Asn (rs6166) polymorphism in the follicle-stimulating hormone receptor (FSHR) gene and polycystic ovarian syndrome (PCOS) in 204 women with PCOS and 204 healthy controls. It found that the A allele and the AA genotype of the FSHR gene were significantly more common in women with PCOS, suggesting a strong association with the condition. Women with the AA genotype also had higher body mass index (BMI), luteinizing hormone (LH) levels, and LH/FSH ratios, while those with the GG genotype had increased basal FSH levels and signs of insulin resistance. The study concluded that the FSHR Ser680Asn polymorphism is linked to PCOS and could potentially be used as a biomarker to assess the risk of developing PCOS in the given population.

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Association of Follicle-Stimulating Hormone Receptor Gene Ser680Asn (rs6166) Polymorphism with Polycystic Ovarian Syndrome

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