Spontaneous Fertility in a Male Patient with Testotoxicosis Despite Suppression of FSH Levels

In a 2018 case report, researchers detailed the unusual case of a 24-year-old male with testotoxicosis who achieved spontaneous fertility despite having suppressed FSH levels. The patient, treated from ages 2.5 to 9.5 for his condition, had extremely high testosterone levels and undetectable gonadotropin levels, yet fathered a healthy child. This case suggests that high intratesticular testosterone may be sufficient for spermatogenesis and fertility, even in the absence of FSH, providing insights into the hormonal regulation of spermatogenesis and fertility potential in cases of hormonal imbalances or genetic mutations.