Hyperinsulinism, Insulin Resistance, and Fertility
January 2005
in “
Elsevier eBooks
”
insulin resistance hyperinsulinism hyperandrogenism polycystic ovarian syndrome PCOS theca cells androgens hirsutism acne seborrhea acanthosis nigricans estrogens aromatization high insulin levels high androgen levels ovarian cells male hormones excessive hair growth skin breakouts oily skin dark skin patches female hormones hormone conversion
TLDR Insulin resistance and hyperinsulinism are linked to fertility issues and can worsen symptoms of PCOS.
The document from 2005 discusses the relationship between insulin resistance (IR), hyperinsulinism, and fertility issues, particularly focusing on their association with hyperandrogenism and polycystic ovarian syndrome (PCOS). It highlights that 25 to 60% of PCOS cases are linked to IR and hyperinsulinism, influenced by genetic, environmental, and weight factors. Insulin and related growth factors stimulate theca cells in the ovary, which are abundant in PCO and specifically secrete androgens. The presence of both IR and PCOS amplifies androgen secretion and skin-related changes such as hirsutism, acne, and seborrhea, along with hyperinsulinism-induced acanthosis nigricans. Androgens and estrogens, through peripheral aromatization, chronically alter feedback mechanisms, blocking ovulation, disrupting menstrual patterns, and leading to subfertility.
