July 2026 in “Aesthetic Plastic Surgery” This pilot study found that intradermal 10% glucose combined with non-cross-linked hyaluronic acid improved hair density and diameter more than hyaluronic acid alone in adults with androgenetic alopecia, with no serious adverse events.
January 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences” In this randomized study, intradermal injections of dutasteride effectively improved androgenetic alopecia in 15 male patients, showing significant clinical improvement within one month and being well-tolerated without notable side effects, though the improvement was negatively correlated with longer disease duration.
November 2025 in “Skin Appendage Disorders” In this study, researchers found that combining topical 5% minoxidil with intradermal triamcinolone microinjections significantly improved hair density in women with androgenetic alopecia compared to minoxidil alone. However, further research is necessary to confirm these findings in a larger population.
April 2025 in “Biomacromolecules” This study developed microneedles loaded with Platycladus orientalis leaf extract to treat androgenic alopecia, finding that they can effectively deliver active ingredients into the dermis, promote hair follicle growth by removing free radicals, and activate the Wnt/β-catenin pathway.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, Platycladus orientalis leaf extract loaded into hyaluronic acid microneedles was found to promote hair follicle growth by enhancing the environment for hair cell proliferation and activating repair pathways, suggesting potential as a treatment for androgenic alopecia.
April 2025 in “Journal of Cosmetic and Laser Therapy” This study found that both microneedle delivery and intradermal injection of platelet-rich plasma were similarly effective for treating androgenetic alopecia, but microneedle delivery caused significantly less pain.
December 2024 in “Biomaterials Research” Delivering specific cell clusters into the skin can help regrow hair in mice.
This study found that both intradermal botulinum toxin A and intradermal minoxidil were equally effective for treating androgenetic alopecia, showing improvement in hair count with advantages like minimal invasiveness and absence of major side effects; minoxidil was also noted to be more cost-effective.
June 2024 in “Georgetown Scientific Research Journal” This study found that intradermal bleomycin injections induced dermal fibrosis in C57BL/6 mice, evidenced by hair follicle obliteration and dermal thickening, though no significant trends in gene expression were observed, indicating the need for further research to understand the link between fibrosis and dyschromia.
June 2024 in “Dermatology and therapy” This study reviewed recent advancements in using botulinum toxin for treating androgenetic alopecia and emphasized the need for further research to determine the most effective injection sites and depths, as current strategies show inconsistent results.
March 2024 in “Intisari Sains Medis” This narrative review reported that intradermal injection of autologous platelet-rich plasma showed objective improvement and increased patient satisfaction in treating periorbital wrinkles, though the authors noted the need for further rigorous studies to confirm these findings.
July 2023 in “Journal of personalized medicine” This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.
July 2023 in “International journal of dermatology, venereology and leprosy sciences” This source reports that intradermal injection treatments may offer more effective solutions for androgenetic alopecia compared to other modalities, although effectiveness can vary among patients.
June 2023 in “Dermatologic Surgery” This review highlights the promising potential of mesotherapy for delivering dutasteride and minoxidil as treatments for androgenetic alopecia, emphasizing the need for more research on drug preparation, delivery, and maintenance to establish its safety and effectiveness.
August 2021 in “Research, Society and Development” In this study, intradermal therapy with Minoxidil, growth factors, and vitamins showed a slight advantage in increasing hair volume over a combination with Finasteride for androgenic alopecia.
September 2017 in “Journal of Investigative Dermatology” RCS-01 is safe and may help rejuvenate aging skin.
This study found that Botox® was most effective at a 25 U/ml concentration, while Dysport® and Neurobloc® were optimal at 100 U/ml for producing anhidrotic areas after injections.
November 2025 in “Revista Políticas Públicas & Cidades” In this case study, the combination of microneedling and intradermal therapy was observed to effectively stimulate hair growth and improve hair density in a menopausal woman with androgenetic alopecia, resulting in enhanced self-esteem and cosmetic satisfaction.
This study observed that both intradermotherapy with 5% minoxidil and topical minoxidil application resulted in perceived improvements in hair density and thickness among patients with androgenetic alopecia, with no significant difference between the two groups.
October 2023 in “Peer review” This review discusses the efficacy and safety of using intradermotherapy combined with platelet-rich plasma for treating alopecia and reports no new clinical results.
November 2022 in “Pakistan Armed Forces Medical Journal” This study found that topical liquid nitrogen improved pain tolerance during intradermal platelet-rich plasma therapy in androgenic alopecia compared to normal saline, although patient satisfaction did not significantly differ between groups.
January 2022 in “Journal of Clinical and Diagnostic Research” This study found that intradermal administration of PRP combined with oral biotin significantly increased hair regrowth in men with androgenetic alopecia, without notable side effects.
July 2021 in “Indian journal of drugs in dermatology” In this study, the combination of intradermal meso-solution and topical 5% minoxidil significantly increased hair re-growth in men with androgenetic alopecia compared to minoxidil alone.
July 2020 in “Journal of The American Academy of Dermatology” This article discusses the authors’ response to comments on their study about intradermal botulinum toxin's effect on androgenetic alopecia, reporting no new findings.
July 2020 in “CRS 2020 Virtual Annual Meeting” This study found that the newly developed microarray patches for intradermal delivery of finasteride showed high drug content and significantly improved skin deposition compared to existing methods.
September 2017 in “Journal of Investigative Dermatology” This study found that intradermal injections of cultured autologous dermal sheath cup cells for androgenetic alopecia showed hair loss stabilization at 24 months without serious adverse effects and a sustained response in some participants.
This study reviewed the efficacy of hair intradermotherapy for treating androgenetic alopecia, finding that the technique, whether used alone or with other interventions, can increase hair density, reduce hair loss, and improve patient self-esteem, although professional supervision is recommended to minimize adverse effects.
January 2023 in “Surgical & Cosmetic Dermatology” This study examined the effectiveness of using intradermotherapy, with or without microneedling and topical solutions, in reducing hair loss among men with androgenetic alopecia, though results are not reported in the abstract.
This study conducted a literature review and found that intradermotherapy, a minimally invasive technique involving needle punctures and drugs like minoxidil and finasteride, appears to be safe and effective for short-term treatment of alopecia, with satisfactory results and no significant side effects.
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January 2012 in “Biological and Pharmaceutical Bulletin” This study found that using a combination of iontophoresis and liposomal delivery facilitated the effective intradermal administration of superoxide dismutase in rats, reducing oxidative skin damage from UV exposure.