Poster Abstract: Novel Dissolving Microarray Patches for Intradermal Delivery of Finasteride

    July 2020 in “ CRS 2020 Virtual Annual Meeting ”
    Alejandro Javier Paredes, Fabiana Volpe Zanutto, Andi Dian Permana, Aidan J. Murphy, Marta Guerini, Jonathan A. Coulter, Ryan F. Donnelly
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    TLDR Researchers developed a new skin patch that delivers more finasteride into the skin, potentially improving treatment for hair loss and prostate issues.
    In 2020, researchers developed novel two-layered dissolving microarray patches (MAPs) for the intradermal delivery of finasteride (FND), a drug used to treat androgenetic alopecia and benign prostatic hyperplasia. The study reported the successful formulation of MAPs using three different silicone molds, resulting in different needle shapes and sizes. The MAPs demonstrated less than 10% needle height reduction upon application of force, indicating good mechanical stability. Insertion tests into a skin simulant and full-thickness neonatal porcine skin showed effective penetration depths, with the amount of FND delivered to the skin being up to 21 times higher than previously reported values in the literature. The results suggest that these MAPs have significant potential for sustained intradermal delivery of FND, which could lead to improved treatment outcomes for patients.
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      community What is worth dissolving in topical minoxidil solution?

      in Treatment  3 upvotes 1 year ago
      Switching from minoxidil foam to topical solution and considering adding caffeine, melatonin, or cetirizine. Currently using 2.5mg oral minoxidil and 1mg oral finasteride, planning to ask for 0.5mg oral dutasteride and 5mg oral minoxidil.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  66 upvotes 2 years ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

      community Early Signs - Notes for diffuse thinners

      in Treatment  10 upvotes 1 month ago
      Diffuse thinning is often due to androgenetic alopecia, and DHT blockers like finasteride are recommended. Treatments mentioned include minoxidil, finasteride, dutasteride, and RU58841, with emphasis on starting early and using a holistic approach.

      community Taking small Finasteride doses

      in Finasteride/Dutasteride  1 upvotes 2 years ago
      The user has been taking small doses of Finasteride, mixed with Stemoxydine, which has helped maintain their existing hair but not regrow new hair. They're considering dissolving the Finasteride in high-alcohol content drinks for easier administration and are seeking opinions on this method.

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