Poster Abstract: Novel Dissolving Microarray Patches for Intradermal Delivery of Finasteride

    July 2020 in “ CRS 2020 Virtual Annual Meeting ”
    Alejandro Javier Paredes, Fabiana Volpe Zanutto, Andi Dian Permana, Aidan J. Murphy, Marta Guerini, Jonathan A. Coulter, Ryan F. Donnelly
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    TLDR Researchers developed a new skin patch that delivers more finasteride into the skin, potentially improving treatment for hair loss and prostate issues.
    In 2020, researchers developed novel two-layered dissolving microarray patches (MAPs) for the intradermal delivery of finasteride (FND), a drug used to treat androgenetic alopecia and benign prostatic hyperplasia. The study reported the successful formulation of MAPs using three different silicone molds, resulting in different needle shapes and sizes. The MAPs demonstrated less than 10% needle height reduction upon application of force, indicating good mechanical stability. Insertion tests into a skin simulant and full-thickness neonatal porcine skin showed effective penetration depths, with the amount of FND delivered to the skin being up to 21 times higher than previously reported values in the literature. The results suggest that these MAPs have significant potential for sustained intradermal delivery of FND, which could lead to improved treatment outcomes for patients.
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      community What is worth dissolving in topical minoxidil solution?

      in Treatment  3 upvotes 3 months ago
      Switching from minoxidil foam to topical solution and considering adding caffeine, melatonin, or cetirizine. Currently using 2.5mg oral minoxidil and 1mg oral finasteride, planning to ask for 0.5mg oral dutasteride and 5mg oral minoxidil.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  66 upvotes 11 months ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

      community CB-03-01: I need help

      in Treatment  7 upvotes 3 years ago
      The user stopped using finasteride and RU58841 and is considering CB-03-01 for androgenic alopecia but is concerned about the cost and effectiveness, especially at a lower dose than in clinical trials. They are also using minoxidil, micro-needling, and nizoral shampoo but are unsure about the correct application method for CB-03-01.

      community Update to fin 0.25 mg, 4x/week

      in Progress Pictures  64 upvotes 1 year ago
      User reported initial hair regrowth with 0.25 mg finasteride taken four times a week, experiencing a second shedding phase, and no side effects. They also mentioned using RU58841 without success and plan to stop after a year.

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