Poster Abstract: Novel Dissolving Microarray Patches for Intradermal Delivery of Finasteride
July 2020
in “
CRS 2020 Virtual Annual Meeting
”
TLDR Researchers developed a new skin patch that delivers more finasteride into the skin, potentially improving treatment for hair loss and prostate issues.
In 2020, researchers developed novel two-layered dissolving microarray patches (MAPs) for the intradermal delivery of finasteride (FND), a drug used to treat androgenetic alopecia and benign prostatic hyperplasia. The study reported the successful formulation of MAPs using three different silicone molds, resulting in different needle shapes and sizes. The MAPs demonstrated less than 10% needle height reduction upon application of force, indicating good mechanical stability. Insertion tests into a skin simulant and full-thickness neonatal porcine skin showed effective penetration depths, with the amount of FND delivered to the skin being up to 21 times higher than previously reported values in the literature. The results suggest that these MAPs have significant potential for sustained intradermal delivery of FND, which could lead to improved treatment outcomes for patients.
