Randomized, Double-Blind, Placebo-Controlled, Single-Center, Phase I Safety Study of Intradermal Injections of Autologous Fibroblasts Isolated from the Non-Bulbar Dermal Sheath of the Hair Follicle to Treat Skin Aging

September 2017 in “ Journal of Investigative Dermatology ”

Susanne Grether‐Beck, Alessandra Marini, Thomas Jaenicke, R. Hoffmann, Jean Krutmann

autologous fibroblasts dermal sheath hair follicle RCS-01 intradermal injections extracellular matrix gene expression analysis cell therapy skin rejuvenation

TLDR RCS-01 is safe and may help rejuvenate aging skin.

The study evaluated the safety and efficacy of RCS-01, a cell therapy product made from autologous fibroblasts isolated from the dermal sheath of hair follicles, in treating skin aging. It involved 21 healthy Caucasian participants aged 50-65, with 13 receiving RCS-01 and 4 receiving a placebo. Injections were administered intradermally into the buttock skin, either once or three times at monthly intervals. The treatment was well tolerated with no severe adverse events reported. Gene expression analysis showed significant upregulation of genes related to extracellular matrix homeostasis, suggesting potential skin rejuvenating properties. However, triple treatments did not show superiority over single treatments. Overall, RCS-01 appeared to be a safe approach with beneficial molecular effects on skin aging.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Chinese reseachers successfully create hair follicles in-vitrofor autologous transplantation in vivo

in Research/Science 28 upvotes 4 months ago

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community Autologus Exosomes, anyone tried it ?

in Technology 2 upvotes 3 months ago

Autologous exosome treatment for hair loss is being discussed as an emerging option. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.

community Is this regrowth? My doctor took these photos and said I looked better.

in Satire 142 upvotes 9 months ago

The conversation humorously discusses an extensive and exaggerated hair loss treatment regimen, including finasteride, dutasteride, minoxidil, pyrilutamide, RU58841, and various other therapies. Despite the numerous treatments, the effectiveness is questioned, and the user humorously considers adding more minoxidil.

community How promising is th RCH-01/Replicel treatment? Is there any new info that suggests it will be as successful as it claims? What other promising treatments are close?

in Technology 13 upvotes 6 years ago

The conversation is about the potential of the RCH-01/Replicel hair loss treatment and its lack of updates since 2013, with the user expressing hope for its success and considering using Minoxidil, finasteride, and dermarolling in the meantime. Other treatments mentioned as promising are Breezula and Tsuji.

community Epibiotech will now offer off-the-shelf allogeneic hair multiplication treatment in South Korea

in Research/Science 81 upvotes 3 years ago

Epibiotech will offer off-the-shelf allogeneic hair multiplication treatment in South Korea, using dermal papilla cells from donors to grow hair in balding areas. This method is cheaper and less invasive than traditional hair transplants.

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Quantitative Analysis of the Anatomical Changes in the Scalp and Hair Follicles in Androgenetic Alopecia Using Magnetic Resonance Imaging

research Quantitative Analysis of the Anatomical Changes in the Scalp and Hair Follicles in Androgenetic Alopecia Using Magnetic Resonance Imaging

2 citations , June 2020 in “Skin Research and Technology”

MRI reveals thinner scalps and smaller hair follicles in people with androgenetic alopecia.