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    Did you mean Interleukin-1 Receptor Antagonist?
    Glossary Interleukin-1 Receptor Antagonist

    naturally occurring protein that inhibits inflammatory molecule interleukin-1

    Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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    1. Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article The Egyptian Journal of Hospital Medicine · 2022 · 1 citations
    2. THE PATHOGENESIS OF ALOPECIA AREATA Dermatologic Clinics · 1996 · 89 citations
    3. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    4. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    5. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    6. 557 A peptide derivative with known anti-wrinkle properties was identified as potent dipeptiylpeptidase-4 inhibitor Journal of Investigative Dermatology · 2016
    7. IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures. PubMed · 1993 · 30 citations
    8. Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture 2014 · 15 citations
    9. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    10. New treatments for rheumatoid arthritis Postgraduate Medicine · 1999 · 13 citations
    11. Drug Repurposing Patent Applications April–June 2021 Assay and drug development technologies · 2021
    12. Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology Hair transplant forum international · 2012 · 1 citations
    13. Dupilumab for the treatment of alopecia areata in children with atopic dermatitis JAAD case reports · 2021 · 7 citations
    14. Nociceptive and Nonnociceptive Roles of TRPV3 and Its “Druggability” Methods in pharmacology and toxicology · 2012
    15. A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations Gene · 2013 · 11 citations
    16. Studying the genetic predisposing factors in the pathogenesis of acne vulgaris Human Immunology · 2011 · 39 citations
    17. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    18. Emerging Therapies for Acne Vulgaris American Journal of Clinical Dermatology · 2018 · 22 citations
    19. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    20. Redefining hormone resistance in prostate cancer Therapeutic Advances in Medical Oncology · 2009 · 38 citations
    21. Androgen Receptor Inhibitors in the Treatment of Acne Vulgaris: Efficacy and Safety Profiles of Clascoterone 1% Cream Clinical Cosmetic and Investigational Dermatology · 2022 · 4 citations
    22. Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist Expert opinion on pharmacotherapy · 2021 · 9 citations
    23. Scarless wound healing: finding the right cells and signals Cell and Tissue Research · 2016 · 132 citations
    24. Recent approaches of antibody therapeutics in androgenetic alopecia Frontiers in Pharmacology · 2024
    25. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity Nature · 2010 · 717 citations
    26. Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling Biomolecules · 2022 · 13 citations
    27. Characterization of Hair Follicle Antigens Targeted by the Anti-Hair Follicle Immune Response Journal of Investigative Dermatology Symposium Proceedings · 2003 · 148 citations
    28. Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives International Journal of Molecular Sciences · 2024 · 9 citations
    29. Interleukin gene polymorphisms and alopecia areata: A systematic review and meta-analysis Medicine · 2024 · 2 citations
    30. Topische Immuntherapie mit Diphenylcyclopropenon bei verschiedenen Typen der Alpecia areata: Assoziation zu klinischen Parametern und einem funktionellen Genpolymorphismus des Interleukin-6-Promotors Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · 2005