January 2016 in “Global dermatology” A treatment called Cellcurin, combined with microneedling, significantly increased hair density and diameter in patients with hair loss.
In this study, mesotherapy using a combination of micronutrients and antioxidants significantly increased hair density in younger women with androgenetic alopecia, with effects lasting 6-12 months, compared to older women.
147 citations
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January 2014 in “American Journal of Clinical Dermatology” This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.
16 citations
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April 2016 in “PLoS ONE” In a porcine model, this study observed that using an External Tissue Expansion Device increased epidermis thickness, cell proliferation, and vessel density at fat graft recipient sites.
64 citations
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March 2017 in “Journal of Cosmetic Dermatology” This meta-analysis suggests that local injection of platelet-rich plasma for androgenic alopecia is associated with an increased number of hairs and some increase in hair thickness, though larger studies are needed for confirmation.
47 citations
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September 2008 in “British Journal of Dermatology” This study found that women with androgenetic alopecia experience diffuse hair loss due to a decrease in terminal hairs and an increase in vellus hairs per follicular unit.
28 citations
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October 2017 in “Journal of Cosmetic and Laser Therapy” This study found that combining microneedle treatments with 5% minoxidil topical solution led to the greatest increase in hair density among Chinese men with androgenetic alopecia.
28 citations
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February 2011 in “Clinical Endocrinology” In this study, women with polycystic ovary syndrome showed adverse lipoprotein profile changes that increase cardiovascular risk, which were found to be more closely related to androgen levels than body weight.
10 citations
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January 2012 in “Annals of Dermatology” In this study, 1.25 mg daily finasteride for 28 weeks showed minimal increase in hair density and thickness in normoandrogenic female pattern hair loss, but no significant clinical improvement was observed.
8 citations
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April 1990 in “Hormone and Metabolic Research” This study found that a combination of cyproterone acetate and ethinyl estradiol over one year did not affect glucose tolerance but increased total cholesterol, HDL cholesterol, and triglycerides in patients with moderate hyperandrogenism.
7 citations
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May 2019 in “Journal of the Formosan Medical Association” This study found that overweight women with polycystic ovary syndrome carrying the HSD3B1 1245C allele had an increased presence of female pattern hair loss compared to those with the wild-type genotype.
4 citations
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August 2019 This study found that elevated free testosterone levels may reduce body fat and increase bone density in males, but also raise the risk of prostate cancer, hair loss, and benign prostate hyperplasia.
May 2026 in “Global Translational Medicine” This study found that ethanol extract of Syzygium aromaticum (clove) leaves significantly improved lipid profiles and increased body weight in testosterone-induced benign prostatic hyperplasia rats, suggesting potential anti-hyperlipidemic effects and modulation of body weight through metabolic activity.
In this simulation study, higher cannabis exposure was associated with increased hair shedding severity and reduced follicular density, with greater effects observed in female-assigned profiles, but these associations are based on modeled data and not clinical observations.
September 2025 in “Journal of Dermatology Research and Therapy” In this study, two male patients with androgenetic alopecia who had previously undergone hair transplants showed increased hair regrowth after receiving verteporfin injections, with a 63% mean increase in dense donor sites, 38% in thinning areas, but no growth in bald areas.
November 2023 in “International Journal of Women's Dermatology” In this study, female patients undergoing hormone replacement therapy showed improvements in frontal hairline appearance and increased hair plucking strength, suggesting positive effects of estradiol on hair growth while excluding age-related factors.
August 2023 in “Stem Cell Research & Therapy” In this study on male androgenetic alopecia, the researchers reported significant increases in hair count, density, and thickness with minimal side effects over 6 weeks using adipose-derived stem cell conditioned media and minoxidil, but found no significant differences between concentrated and non-concentrated treatments.
March 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, hair follicle stem cells were reported to accelerate burn wound healing and increase tissue tensile strength in rats.
January 2017 in “Journal of Cosmetics, Dermatological Sciences and Applications” Among Chinese women, this study observed that hair density decreases and scalp erythema increases with age, with most aging features like hair diameter and sebum content peaking in their 40s.
In this study, ground flaxseed intake was associated with increased hair growth and improved metabolic markers in rabbits, but the mechanisms and optimal usage remain to be determined.
In this study, FGF5-knockout Dorper sheep generated using CRISPR/Cas9 showed increased fine-wool and active hair-follicle density, suggesting potential therapeutic applications for androgen alopecia.
February 2021 in “Dermatological reviews” In this study, a specially adapted nonablative radiofrequency device significantly increased hair growth measures in most patients with androgenetic alopecia, including hair count and density.
October 2020 in “El-Minia Medical Bulletin” In this study, 20 patients with androgenetic alopecia experienced clinical improvement characterized by increased hair growth and density after using topical minoxidil for 3 to 12 months, suggesting its effectiveness as a treatment option for both men and women.
In this study, microneedling radiofrequency followed by topical exosome application was associated with significant increases in hair density and diameter, showing promising potential as a therapy for pattern hair loss.
In this study, minoxidil combined with PRP was found to effectively increase hair density in women with female pattern hair loss, but showed no superiority over minoxidil alone. No major side effects were reported.
August 2025 in “International Journal of Scientific Research” This study found that administering 5 mg of oral minoxidil daily for 24 weeks led to a 20.3% increase in hair density among men with androgenetic alopecia, although side effects like hypertrichosis and hypotension were observed.
September 2024 in “British journal of surgery” In this study, autologous stem cell therapy was associated with a 29% increase in hair density in androgenetic alopecia patients over six months, suggesting potential for further investigation.
June 2024 in “British Journal of Dermatology” This study found that combining platelet-rich plasma with topical minoxidil led to the greatest increase in terminal hair density at 32 weeks, while low-dose oral minoxidil was more effective at reducing vellus hair density in men with androgenetic alopecia.
February 2011 in “Vestnik dermatologii i venerologii” This study observed a decrease in hair density and average hair diameter, along with an increase in hair loss, among females with androgenic alopecia compared to healthy controls.
In this study, mesotherapy containing nutritional supplements was found to increase patient satisfaction and improve the number of hair follicles more effectively than topical minoxidil in treating female pattern hair loss, though both methods showed similar overall efficacy in hair density and hair loss reduction.