Modeling Oxidative Stress-Linked Telogen Effluvium: A Monte Carlo Simulation Using Published Trichoscopy Norms and Cannabis Exposure Distributions

This study used a Monte Carlo simulation to explore the potential link between cannabis exposure and telogen effluvium, a form of hair loss, in a synthetic dataset of 140 individuals. The simulation incorporated published data on follicular density, cannabis use, and hair loss-related quality of life measures. Results indicated that higher cannabis exposure was associated with increased severity of hair loss symptoms (r = 0.31, p < 0.01) and decreased follicular density (r = -0.38, p < 0.05), with stronger effects observed in female-assigned profiles. While these findings suggest a possible connection between cannabis use and hair loss, they are based on modeled data and cannot establish causality. The study highlights the potential of using computational modeling to generate hypotheses about cannabis exposure and hair loss, suggesting the need for future research incorporating empirical data to validate these findings.