Modeling Oxidative Stress-Linked Telogen Effluvium Using Monte Carlo Simulation of Published Trichoscopy Norms and Cannabis Exposure Distributions

This study utilized a Monte Carlo simulation to investigate the potential link between cannabis exposure and telogen effluvium, a type of hair loss, using a synthetic dataset of 140 subjects. The findings indicated that higher cannabis exposure was associated with increased hair shedding severity (r = 0.31, p < 0.01) and decreased follicular density (r = -0.38, p < 0.05), with these associations remaining significant after adjusting for demographic factors, particularly in females. Although based on simulated data, the study suggests that cannabis exposure may contribute to hair shedding patterns similar to telogen effluvium and underscores the need for clinical research to validate these findings and explore the underlying biological mechanisms.